| Acute bacterial skin and skin structure infection

Orbactiv vs Baxdela

Side-by-side clinical, coverage, and cost comparison for acute bacterial skin and skin structure infection.

Deep comparison between: Orbactiv vs Baxdela with Prescriber.AI

AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.

Safety signalsBaxdela has a higher rate of injection site reactions vs Orbactiv based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Baxdela but not Orbactiv, including UnitedHealthcare

Category

Orbactiv

Baxdela

At A Glance

RouteIV infusion

FrequencySingle dose

ClassLipoglycopeptide antibacterial

RouteIV infusion or Oral

FrequencyEvery 12 hours

ClassFluoroquinolone antibacterial

Indications

Acute bacterial skin and skin structure infection

Acute bacterial skin and skin structure infection
Community-Acquired Pneumonia

Dosing

Acute bacterial skin and skin structure infection 1,200 mg as a single dose by IV infusion over 3 hours in patients 18 years and older.

Acute bacterial skin and skin structure infection 300 mg IV infusion every 12 hours over 60 minutes, or 450 mg orally every 12 hours, for 5-14 days; IV dose reduced to 200 mg every 12 hours in patients with eGFR 15-29 mL/min/1.73m2.

Community-Acquired Pneumonia 300 mg IV infusion every 12 hours over 60 minutes, or 450 mg orally every 12 hours, for 5-10 days; IV dose reduced to 200 mg every 12 hours in patients with eGFR 15-29 mL/min/1.73m2.

Contraindications

Concomitant use of intravenous unfractionated heparin sodium within 120 hours (5 days) after ORBACTIV administration due to falsely elevated aPTT test results
Known hypersensitivity to oritavancin products

Known hypersensitivity to delafloxacin, any fluoroquinolone antibacterial, or any component of BAXDELA

Drug Interactions

971View drug interactions

1299View drug interactions

Adverse Reactions

Most common (>=3%) Headache, nausea, vomiting, limb and subcutaneous abscesses, diarrhea.

Serious Cellulitis, hypersensitivity reactions, infusion-related reactions, Clostridioides difficile-associated diarrhea, osteomyelitis.

Most common (>=2%) Nausea, diarrhea, headache, transaminase elevations, vomiting

Serious Tendinitis and tendon rupture, peripheral neuropathy, CNS effects, hypersensitivity reactions, Clostridioides difficile-associated diarrhea, blood glucose disturbances

Pharmacology

Oritavancin is a semisynthetic lipoglycopeptide antibacterial that inhibits transglycosylation and transpeptidation steps of cell wall biosynthesis and disrupts bacterial membrane integrity, producing concentration-dependent bactericidal activity against susceptible Gram-positive organisms; antimicrobial activity correlates with the AUC/MIC ratio.

Delafloxacin is a fluoroquinolone antibacterial that inhibits bacterial topoisomerase IV and DNA gyrase, enzymes required for bacterial DNA replication, transcription, repair, and recombination, exhibiting concentration-dependent bactericidal activity against gram-positive and gram-negative organisms.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Orbactiv