| Amyotrophic Lateral Sclerosis
Qalsody vs Tiglutik
Side-by-side clinical, coverage, and cost comparison for amyotrophic lateral sclerosis.Deep comparison between: Qalsody vs Tiglutik with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTiglutik has a higher rate of injection site reactions vs Qalsody based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tiglutik but not Qalsody, including UnitedHealthcare
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Category
Qalsody
Tiglutik
At A Glance
Intrathecal injection
Every 14 days (loading), then every 28 days
Antisense oligonucleotide
Oral
Every 12 hours
Benzothiazole
Indications
- Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
Dosing
Amyotrophic Lateral Sclerosis 100 mg (15 mL) intrathecally; 3 loading doses at 14-day intervals, then 100 mg every 28 days thereafter.
Amyotrophic Lateral Sclerosis 50 mg (10 mL) orally or via PEG-tube twice daily every 12 hours, taken at least 1 hour before or 2 hours after a meal.
Contraindications
—
- History of severe hypersensitivity reactions to riluzole or to any of its components (anaphylaxis has occurred)
Adverse Reactions
Most common (>=10%) Pain, fatigue, arthralgia, CSF white blood cell increased, myalgia
Serious Myelitis and/or radiculitis, papilledema and elevated intracranial pressure, aseptic meningitis
Most common (>=5%) Asthenia, nausea, decreased lung function, hypertension, abdominal pain
Serious Hepatic injury, neutropenia, interstitial lung disease
Postmarketing Acute hepatitis, icteric toxic hepatitis, renal tubular impairment, pancreatitis
Pharmacology
Tofersen is an antisense oligonucleotide (ASO) that binds to SOD1 mRNA, causing its degradation and reducing SOD1 protein synthesis; it is not a substrate for, or inhibitor or inducer of, CYP450 enzymes.
The mechanism by which riluzole exerts its therapeutic effects in patients with ALS is unknown; its clinical pharmacodynamics have not been determined in humans.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Qalsody
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (4/12)
Tiglutik
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Qalsody
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Tiglutik
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Qalsody
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Tiglutik
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Amyotrophic Lateral Sclerosis (ALS): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$50/fillfill
Tiglutik Co-pay SupportCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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QalsodyView full Qalsody profile
TiglutikView full Tiglutik profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.