| Amyotrophic Lateral Sclerosis
Radicava vs Qalsody
Side-by-side clinical, coverage, and cost comparison for amyotrophic lateral sclerosis.Deep comparison between: Radicava vs Qalsody with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsQalsody has a higher rate of injection site reactions vs Radicava based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Qalsody but not Radicava, including UnitedHealthcare
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Category
Radicava
Qalsody
At A Glance
IV infusion or Oral
Daily (cyclic dosing schedule)
Intrathecal injection
Every 14 days (loading), then every 28 days
Antisense oligonucleotide
Indications
- Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
Dosing
Amyotrophic Lateral Sclerosis RADICAVA 60 mg IV infusion over 60 minutes or RADICAVA ORS 105 mg (5 mL) orally/via feeding tube in the morning after overnight fasting; initial cycle: daily for 14 days then 14-day drug-free period; subsequent cycles: daily for 10 days out of 14-day periods then 14-day drug-free periods.
Amyotrophic Lateral Sclerosis 100 mg (15 mL) intrathecally; 3 loading doses at 14-day intervals, then 100 mg every 28 days thereafter.
Contraindications
- History of hypersensitivity to edaravone or any inactive ingredient in this product
—
Adverse Reactions
Most common (>=2%) contusion, gait disturbance, headache, dermatitis, eczema, respiratory failure/disorder/hypoxia, glycosuria, tinea infection
Serious hypersensitivity reactions, sulfite allergic reactions
Postmarketing hypersensitivity reactions, anaphylaxis
Most common (>=10%) Pain, fatigue, arthralgia, CSF white blood cell increased, myalgia
Serious Myelitis and/or radiculitis, papilledema and elevated intracranial pressure, aseptic meningitis
Pharmacology
Edaravone is a substituted 2-pyrazolin-5-one whose therapeutic mechanism in ALS is unknown. At exposures at least 5 times the recommended dose, edaravone does not prolong the QT interval to any clinically relevant extent.
Tofersen is an antisense oligonucleotide (ASO) that binds to SOD1 mRNA, causing its degradation and reducing SOD1 protein synthesis; it is not a substrate for, or inhibitor or inducer of, CYP450 enzymes.
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Most Common Insurance
Anthem BCBS
Radicava
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (0/12)
Qalsody
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (4/12)
UnitedHealthcare
Radicava
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Qalsody
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Radicava
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Qalsody
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Radicava.
Cost estimate not availableAssistance Fund: Amyotrophic Lateral Sclerosis (ALS): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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RadicavaView full Radicava profile
QalsodyView full Qalsody profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.