| Angioedemas, Hereditary
Ruconest vs Cinryze
Side-by-side clinical, coverage, and cost comparison for angioedemas, hereditary.Deep comparison between: Ruconest vs Cinryze with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCinryze has a higher rate of injection site reactions vs Ruconest based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cinryze but not Ruconest, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Ruconest
Cinryze
At A Glance
IV injection
As needed (up to 2 doses/24 hours)
C1 esterase inhibitor (recombinant)
IV infusion
Every 3-4 days
C1 esterase inhibitor (serpin)
Indications
- Angioedemas, Hereditary
- Angioedemas, Hereditary
Dosing
Angioedemas, Hereditary 50 U/kg IV (max 4200 U) by slow intravenous injection over approximately 5 minutes; a second dose at the same level may be given if symptoms persist; no more than 2 doses within 24 hours.
Angioedemas, Hereditary (adults and adolescents 12 years and above) 1,000 IU IV every 3 or 4 days at 1 mL/min (10 min); for inadequate responders, doses up to 2,000 IU (not exceeding 80 IU/kg) every 3 or 4 days may be considered.
Angioedemas, Hereditary (pediatric patients 6-11 years) 500 IU IV every 3 or 4 days at 1 mL/min (5 min); dose may be adjusted up to 1,000 IU every 3 or 4 days based on individual response.
Contraindications
- History of allergy to rabbits or rabbit-derived products
- History of life-threatening immediate hypersensitivity reactions to C1 esterase inhibitor preparations, including anaphylaxis
- Life-threatening immediate hypersensitivity reactions, including anaphylaxis, to CINRYZE or any of its excipients
Adverse Reactions
Most common (>=2%) Headache, nausea, diarrhea
Serious Anaphylaxis
Postmarketing Abdominal pain, rash
Most common (>=5%) Headache, nausea, rash, vomiting, fever
Serious Cerebrovascular accident
Postmarketing Local infusion site reactions (inflammation or hematoma at infusion site), hypersensitivity
Pharmacology
Recombinant C1 esterase inhibitor (C1INH) that regulates the complement and contact system pathways by irreversibly binding target proteases (activated C1s, kallikrein, factor XIIa, factor XIa), restoring functional C1INH activity and suppressing the bradykinin-mediated vascular permeability increases that underlie HAE attacks.
C1 esterase inhibitor (serpin) that regulates complement and intrinsic coagulation (contact system) pathway activation; suppresses contact system activation by inactivating plasma kallikrein and factor XIIa, modulating vascular permeability by preventing bradykinin generation.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Ruconest
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (3/12) · Qty limit (9/12)
Cinryze
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Ruconest
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (4/8)
Cinryze
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Ruconest
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (2/3)
Cinryze
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
RuconestView full Ruconest profile
CinryzeView full Cinryze profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.