| Asthma
Advair HFA vs Tezspire
Side-by-side clinical, coverage, and cost comparison for asthma.Deep comparison between: Advair Hfa vs Tezspire with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTezspire has a higher rate of injection site reactions vs Advair Hfa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tezspire but not Advair Hfa, including UnitedHealthcare
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Category
Advair Hfa
Tezspire
At A Glance
Oral inhalation
Twice daily
ICS/LABA combination
SC injection
Every 4 weeks
TSLP blocker
Indications
- Asthma
- Asthma
- Chronic rhinosinusitis with multiple nasal polyps
Dosing
Asthma 2 oral inhalations (45 mcg/21 mcg, 115 mcg/21 mcg, or 230 mcg/21 mcg) twice daily approximately 12 hours apart; starting strength based on asthma severity; maximum 2 inhalations of 230 mcg/21 mcg twice daily.
Asthma, Chronic rhinosinusitis with multiple nasal polyps 210 mg administered subcutaneously once every 4 weeks.
Contraindications
- Primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required
- Hypersensitivity to any ingredient of ADVAIR HFA
- Known hypersensitivity to tezepelumab-ekko or any of its excipients
Adverse Reactions
Most common (>=3%) Upper respiratory tract infection, throat irritation, headache, nausea and vomiting, musculoskeletal pain, upper respiratory inflammation, viral respiratory infection, hoarseness/dysphonia, dizziness, viral gastrointestinal infection, gastrointestinal signs and symptoms, muscle pain
Serious Serious asthma-related events (hospitalizations, intubations, death), oropharyngeal candidiasis, pneumonia in COPD patients, immunosuppression and risk of infections, hypercorticism and adrenal suppression, cardiovascular and CNS effects, reduction in bone mineral density, growth effects, glaucoma and cataracts
Postmarketing Arrhythmias, hypertension, ventricular tachycardia, Cushing's syndrome, osteoporosis, cataracts, glaucoma, anaphylaxis, esophageal candidiasis, paradoxical bronchospasm, agitation, depression
Most common (>=3%) Nasopharyngitis, upper respiratory tract infection, pharyngitis, arthralgia, back pain, epistaxis, influenza, injection site reaction
Serious Serious cardiac adverse events (incidence rate 1.08 per 100 patient-years in TEZSPIRE vs 0.21 in placebo in long-term extension trial)
Postmarketing Anaphylaxis
Pharmacology
ADVAIR HFA combines fluticasone propionate, a synthetic trifluorinated corticosteroid with broad anti-inflammatory activity via glucocorticoid receptor binding, and salmeterol, a selective long-acting beta2-adrenoceptor agonist (LABA) that relaxes bronchial smooth muscle by stimulating adenyl cyclase to increase cyclic AMP levels.
TSLP blocker; tezepelumab-ekko is a human monoclonal antibody (IgG2lambda) that binds human thymic stromal lymphopoietin (TSLP) and blocks its interaction with the heterodimeric TSLP receptor, thereby reducing inflammatory biomarkers including blood eosinophils, IgE, FeNO, IL-5, and IL-13.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Advair Hfa
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (12/12)
Tezspire
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Advair Hfa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (5/8)
Tezspire
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (4/8) · Qty limit (0/8)
Humana
Advair Hfa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Tezspire
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Advair Hfa.
Cost estimate not availableAccessia Health: Asthma - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.