| Atrial Fibrillation
Multaq vs Eliquis
Side-by-side clinical, coverage, and cost comparison for atrial fibrillation.Deep comparison between: Multaq vs Eliquis with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEliquis has a higher rate of injection site reactions vs Multaq based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Eliquis but not Multaq, including UnitedHealthcare
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Category
Multaq
Eliquis
At A Glance
Oral
Twice daily
Multi-class antiarrhythmic
Oral
Twice daily
Factor Xa inhibitor
Indications
- Atrial Fibrillation
- Atrial Fibrillation
- Deep Vein Thrombosis
- Pulmonary Embolism
- Venous Thromboembolism
Dosing
Atrial Fibrillation 400 mg twice daily orally; one tablet with the morning meal and one tablet with the evening meal.
Atrial Fibrillation 5 mg orally twice daily; 2.5 mg twice daily in patients with at least 2 of the following: age >=80 years, body weight <=60 kg, or serum creatinine >=1.5 mg/dL.
Deep Vein Thrombosis (prophylaxis, hip or knee replacement) 2.5 mg orally twice daily initiated 12-24 hours post-surgery; 35 days for hip replacement, 12 days for knee replacement.
Deep Vein Thrombosis, Pulmonary Embolism (treatment) 10 mg orally twice daily for 7 days, then 5 mg twice daily.
Deep Vein Thrombosis, Pulmonary Embolism (recurrence reduction) 2.5 mg orally twice daily after at least 6 months of treatment for DVT or PE.
Venous Thromboembolism (pediatric) Weight-based dosing orally twice daily following at least 5 days of initial anticoagulant treatment; doses range from 0.3 mg to 10 mg twice daily based on weight tier.
Contraindications
- Permanent atrial fibrillation (patients in whom normal sinus rhythm will not or cannot be restored)
- Symptomatic heart failure with recent decompensation requiring hospitalization or NYHA Class IV symptoms
- Second or third-degree atrioventricular (AV) block, or sick sinus syndrome (except when used in conjunction with a functioning pacemaker)
- Bradycardia
- Concomitant use of strong CYP3A inhibitors (ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, ritonavir)
- Concomitant use of erythromycin
- Concomitant use of QT-prolonging drugs or herbal products (phenothiazine antipsychotics, tricyclic antidepressants, certain oral macrolide antibiotics, Class I and III antiarrhythmics)
- Liver or lung toxicity related to previous use of amiodarone
- QTc interval >500 ms or PR interval >280 ms
- Severe hepatic impairment
- Hypersensitivity to the active substance or to any of the excipients
- Active pathological bleeding
- Severe hypersensitivity reaction to apixaban (e.g., anaphylactic reactions)
Adverse Reactions
Most common (>=1%) Diarrhea, nausea, abdominal pain, vomiting, dyspepsia, asthenia, bradycardia, skin rash
Serious New or worsening heart failure, liver injury, pulmonary toxicity, QT prolongation, hypokalemia and hypomagnesemia with potassium-depleting diuretics
Postmarketing New or worsening heart failure, atrial flutter with 1:1 AV conduction, liver injury, interstitial lung disease (pneumonitis, pulmonary fibrosis), anaphylactic reactions including angioedema, vasculitis including leukocytoclastic vasculitis
Most common (>=1%) Epistaxis, contusion, hematuria, menorrhagia, hematoma, hemoptysis, rectal hemorrhage, gingival bleeding, nausea, anemia.
Serious Major bleeding including intracranial hemorrhage, gastrointestinal bleeding, and fatal bleeding.
Pharmacology
Dronedarone is an antiarrhythmic agent with properties belonging to all four Vaughan-Williams classes (I, II, III, and IV), though the mechanism of action and contribution of each class to the clinical effect is unknown; it also acts as a moderate inhibitor of CYP3A and CYP2D6 and inhibits P-glycoprotein transport.
Apixaban is a selective inhibitor of factor Xa (FXa) that does not require antithrombin III for antithrombotic activity; by inhibiting free and clot-bound FXa and prothrombinase activity, it decreases thrombin generation and thrombus development without directly affecting platelet aggregation.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Multaq
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (12/12)
Eliquis
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Multaq
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (3/8)
Eliquis
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Humana
Multaq
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Eliquis
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Multaq.
No savings programs available for Eliquis.
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MultaqView full Multaq profile
EliquisView full Eliquis profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.