| Atrial Fibrillation
Xarelto vs Sotylize
Side-by-side clinical, coverage, and cost comparison for atrial fibrillation.Deep comparison between: Xarelto vs Sotylize with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSotylize has a higher rate of injection site reactions vs Xarelto based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sotylize but not Xarelto, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Xarelto
Sotylize
At A Glance
Oral
Once or twice daily
Factor Xa inhibitor
Oral
Twice daily
Class II/III antiarrhythmic
Indications
- Atrial Fibrillation
- Deep Vein Thrombosis
- Pulmonary Embolism
- Venous Thrombosis
- Coronary heart disease
- Peripheral Arterial Diseases
- Ventricular arrhythmia
- Atrial Fibrillation
- Atrial Flutter
Dosing
Atrial Fibrillation 20 mg once daily with evening meal (CrCl >50 mL/min); 15 mg once daily with evening meal (CrCl <=50 mL/min), oral.
Deep Vein Thrombosis, Pulmonary Embolism 15 mg twice daily with food for 21 days, then 20 mg once daily with food for remaining treatment, oral.
Venous Thrombosis 10 mg once daily with or without food: for recurrence prevention after at least 6 months of standard anticoagulant treatment; or 35 days post-hip replacement surgery; or 12 days post-knee replacement surgery; or 31-39 days total for prophylaxis in acutely ill medical patients, oral.
Coronary heart disease, Peripheral Arterial Diseases 2.5 mg twice daily with or without food, in combination with aspirin 75-100 mg once daily, oral.
Ventricular arrhythmia Initial 80 mg orally twice daily; increase by 80 mg/day every 3 days to a maximum 320 mg/day, with therapeutic response typically at 160-320 mg/day in two or three divided doses.
Atrial Fibrillation, Atrial Flutter Initial 80 mg orally twice daily; increase by 80 mg/day every 3 days provided QTc <500 msec; most patients respond at 120 mg twice daily.
Contraindications
- Active pathological bleeding
- Severe hypersensitivity reaction to rivaroxaban or any excipient (e.g., anaphylactic reactions)
- Baseline QT interval >450 msec
- Sinus bradycardia, sick sinus syndrome, or second and third degree AV block without a functioning pacemaker
- Congenital or acquired long QT syndromes
- Cardiogenic shock or decompensated heart failure
- Hypokalemia
- Bronchial asthma or related bronchospastic conditions
- Hypersensitivity to sotalol
Adverse Reactions
Most common Bleeding complications, wound secretion, pruritus, back pain, abdominal pain, muscle spasm, dizziness, fatigue
Serious Intracranial hemorrhage, gastrointestinal bleeding, fatal bleeding, spinal/epidural hematoma
Postmarketing Agranulocytosis, thrombocytopenia, jaundice, cholestasis, hepatitis, hypersensitivity, anaphylactic reaction, anaphylactic shock, angioedema, hemiparesis, anticoagulant-related nephropathy, eosinophilic pneumonia, Stevens-Johnson syndrome, DRESS, atraumatic splenic rupture
Most common (>=2%) Fatigue, bradycardia, dyspnea, proarrhythmia, asthenia, dizziness.
Serious Sustained ventricular tachycardia/ventricular fibrillation, Torsade de Pointes.
Postmarketing Emotional liability, slightly clouded sensorium, incoordination, vertigo, paralysis, thrombocytopenia, eosinophilia, leukopenia, photosensitivity reaction, fever, pulmonary edema, hyperlipidemia, myalgia, pruritus, alopecia.
Pharmacology
Rivaroxaban is a selective oral Factor Xa (FXa) inhibitor that does not require a cofactor for activity; by inhibiting free FXa and prothrombinase activity, it decreases thrombin generation and indirectly inhibits thrombin-induced platelet aggregation.
Sotalol is a non-cardioselective beta-adrenoreceptor blocker (Vaughan Williams Class II) with cardiac action potential duration prolongation (Class III) antiarrhythmic properties; it slows heart rate, decreases AV nodal conduction, and increases refractory periods of atrial and ventricular muscle and conduction tissue.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Xarelto
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (12/12)
Sotylize
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Xarelto
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Sotylize
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Xarelto
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Sotylize
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10/fillfill
Xarelto withMe Savings ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availablePAF Co-Pay Relief: Cardiac Arrhythmias
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
XareltoView full Xarelto profile
SotylizeView full Sotylize profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.