| Carcinoma breast stage IV
Arimidex vs Perjeta
Side-by-side clinical, coverage, and cost comparison for carcinoma breast stage iv.Deep comparison between: Arimidex vs Perjeta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsPerjeta has a higher rate of injection site reactions vs Arimidex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Perjeta but not Arimidex, including UnitedHealthcare
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Category
Arimidex
Perjeta
At A Glance
Oral
Daily
Aromatase inhibitor
IV infusion
Every 3 weeks
HER2/neu receptor antagonist
Indications
- Malignant neoplasm of breast
- Locally advanced breast cancer
- Carcinoma breast stage IV
- Carcinoma breast stage IV
- Locally Advanced Breast Carcinoma
- Inflammatory Breast Carcinoma
- Early Stage HER2-Positive Breast Carcinoma
Dosing
Malignant neoplasm of breast 1 mg tablet orally once daily; adjuvant treatment duration in the ATAC trial was 5 years.
Locally advanced breast cancer, Carcinoma breast stage IV 1 mg tablet orally once daily; continue until tumor progression.
Carcinoma breast stage IV Initial 840 mg IV over 60 min, then 420 mg IV every 3 weeks; administered with trastuzumab and docetaxel.
Locally Advanced Breast Carcinoma, Inflammatory Breast Carcinoma, Early Stage HER2-Positive Breast Carcinoma Initial 840 mg IV, then 420 mg IV every 3 weeks with trastuzumab and chemotherapy; neoadjuvant: 3-6 preoperative cycles followed by postoperative continuation to complete 1 year; adjuvant: 1 year total (up to 18 cycles), starting Day 1 of first taxane-containing cycle.
Contraindications
- Hypersensitivity to anastrozole or any excipient (including anaphylaxis, angioedema, and urticaria)
- Known hypersensitivity to pertuzumab or any of its excipients
Adverse Reactions
Most common (>=10%) Hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, bone pain, peripheral edema, increased cough, dyspnea, pharyngitis, lymphedema
Serious Skin lesions, ulcers, or blisters; severe allergic reactions with swelling of face, lips, tongue, and/or throat; liver function abnormalities including hepatitis
Postmarketing Hepatobiliary events (increases in alkaline phosphatase, ALT, AST, gamma-GT, and bilirubin; hepatitis), erythema multiforme, Stevens-Johnson syndrome, angioedema, urticaria, anaphylaxis, myalgia, hypercalcemia, tendon disorders including tendon rupture and tendonitis
Most common (>30%) diarrhea, alopecia, neutropenia, nausea, fatigue, rash, peripheral neuropathy
Serious neutropenia, febrile neutropenia, leukopenia, diarrhea, peripheral neuropathy, anemia, asthenia, fatigue
Pharmacology
Anastrozole is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by blocking the aromatase enzyme, significantly lowering serum estradiol concentrations in postmenopausal women without affecting adrenal corticosteroid or aldosterone formation.
Pertuzumab is a HER2/neu receptor antagonist that blocks ligand-dependent heterodimerization of HER2 with other HER family members (EGFR, HER3, HER4), inhibiting MAP kinase and PI3K signaling pathways to cause cell growth arrest and apoptosis; it also mediates antibody-dependent cell-mediated cytotoxicity (ADCC).
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Most Common Insurance
Anthem BCBS
Arimidex
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (0/12)
Perjeta
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Arimidex
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Perjeta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Arimidex
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Perjeta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Breast Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Perjeta.
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ArimidexView full Arimidex profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.