| Chemotherapy-induced nausea and vomiting
Akynzeo vs Syndros
Side-by-side clinical, coverage, and cost comparison for chemotherapy-induced nausea and vomiting.Deep comparison between: Akynzeo vs Syndros with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSyndros has a higher rate of injection site reactions vs Akynzeo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Syndros but not Akynzeo, including UnitedHealthcare
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Category
Akynzeo
Syndros
At A Glance
Oral or IV infusion
Once per chemotherapy cycle
NK-1 / 5-HT3 receptor antagonist
Oral
Cannabinoid
Indications
- Chemotherapy-induced nausea and vomiting
- Anorexia
- Chemotherapy-induced nausea and vomiting
Dosing
Chemotherapy-induced nausea and vomiting 1 capsule orally 1 hour before, or 1 vial IV over 30 minutes starting 30 minutes before, each chemotherapy cycle; administer with dexamethasone.
Anorexia 2.1 mg orally twice daily, one hour before lunch and one hour before dinner; may titrate up to 4.2 mg before lunch and 4.2 mg before dinner; maximum 8.4 mg twice daily.
Chemotherapy-induced nausea and vomiting 4.2 mg/m2 orally 1 to 3 hours prior to chemotherapy, then every 2 to 4 hours after chemotherapy for 4 to 6 doses per day; may titrate in increments of 2.1 mg/m2; maximum 12.6 mg/m2 per dose.
Contraindications
—
- History of hypersensitivity reaction to dronabinol
- History of hypersensitivity reaction to alcohol
- Concurrent or recent use of disulfiram- or metronidazole-containing products within 14 days
Adverse Reactions
Most common (>=3%) Headache, asthenia, fatigue, dyspepsia, constipation, erythema
Serious Hypersensitivity reactions, serotonin syndrome
Most common (>=3%) abdominal pain, dizziness, euphoria, nausea, paranoid reaction, somnolence, thinking abnormal, vomiting
Serious neuropsychiatric adverse reactions, hemodynamic instability, seizures, paradoxical nausea/vomiting/abdominal pain, toxicity in preterm neonates
Postmarketing fatigue, hypersensitivity reactions (lip swelling, hives, rash), fall, seizures, disorientation, movement disorder, loss of consciousness, delirium, insomnia, panic attack, syncope
Pharmacology
Netupitant is a selective NK-1 receptor antagonist that blocks substance P-mediated delayed emesis; palonosetron is a 5-HT3 receptor antagonist that inhibits serotonin-mediated acute emesis at vagal afferents and the chemoreceptor trigger zone.
Dronabinol is an orally active cannabinoid that exerts complex effects on the CNS, including central sympathomimetic activity, mediated through cannabinoid receptors in neural tissues.
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Most Common Insurance
Anthem BCBS
Akynzeo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (9/12)
Syndros
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Akynzeo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Syndros
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Akynzeo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Syndros
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Akynzeo.
Cost estimate not availableHealthWell: Chemotherapy Induced Nausea or Vomiting - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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AkynzeoView full Akynzeo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.