| Chronic Obstructive Airway Disease
Stiolto Respimat vs Yupelri
Side-by-side clinical, coverage, and cost comparison for chronic obstructive airway disease.Deep comparison between: Stiolto Respimat vs Yupelri with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsYupelri has a higher rate of injection site reactions vs Stiolto Respimat based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Yupelri but not Stiolto Respimat, including UnitedHealthcare
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Category
Stiolto Respimat
Yupelri
At A Glance
Oral inhalation
Once daily
LAMA/LABA
Inhaled (nebulizer)
Once daily
Long-acting muscarinic antagonist
Indications
- Chronic Obstructive Airway Disease
- Bronchitis, Chronic
- Pulmonary Emphysema
- Chronic Obstructive Airway Disease
Dosing
Chronic Obstructive Airway Disease, Bronchitis, Chronic, Pulmonary Emphysema Two inhalations once-daily at the same time of day via the STIOLTO RESPIMAT inhaler; do not use more than two inhalations every 24 hours.
Chronic Obstructive Airway Disease 175 mcg (one unit-dose vial) inhaled once daily via standard jet nebulizer with mouthpiece.
Contraindications
- Use of LABA without inhaled corticosteroid in patients with asthma
- Hypersensitivity to tiotropium, ipratropium, olodaterol, or any component of this product
- Hypersensitivity to revefenacin or any component of this product
Adverse Reactions
Most common (>3%) nasopharyngitis, cough, back pain
Serious COPD exacerbation, pneumonia
Most common (>=2%) Cough, nasopharyngitis, upper respiratory tract infection, headache, back pain
Serious Paradoxical bronchospasm, worsening of narrow-angle glaucoma, worsening of urinary retention, immediate hypersensitivity reactions
Postmarketing Dry mouth
Pharmacology
Stiolto Respimat combines tiotropium, a long-acting muscarinic antagonist that inhibits M3-receptors at airway smooth muscle to produce bronchodilation, and olodaterol, a LABA that activates beta2-adrenoceptors to stimulate cAMP synthesis and relax airway smooth muscle cells.
Revefenacin is a long-acting muscarinic antagonist (anticholinergic) that competitively and reversibly inhibits M3 receptors at airway smooth muscle, leading to bronchodilation predominantly through a site-specific effect following inhalation.
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Most Common Insurance
Anthem BCBS
Stiolto Respimat
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (11/12)
Yupelri
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (6/12) · Qty limit (4/12)
UnitedHealthcare
Stiolto Respimat
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Yupelri
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (4/8)
Humana
Stiolto Respimat
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Yupelri
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Stiolto Respimat.
Cost estimate not availableAssistance Fund: Chronic Obstructive Pulmonary Disease (COPD)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Stiolto RespimatView full Stiolto Respimat profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.