| Complicated intra-abdominal infection
Xerava vs Recarbrio
Side-by-side clinical, coverage, and cost comparison for complicated intra-abdominal infection.Deep comparison between: Xerava vs Recarbrio with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRecarbrio has a higher rate of injection site reactions vs Xerava based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Recarbrio but not Xerava, including UnitedHealthcare
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Category
Xerava
Recarbrio
At A Glance
IV infusion
Every 12 hours
Fluorocycline antibacterial (tetracycline class)
IV infusion
Every 6 hours
Carbapenem + beta-lactamase inhibitor
Indications
- Complicated intra-abdominal infection
- Hospital acquired bacterial pneumonia
- VABP
- Complicated urinary tract infection
- Pyelonephritis
- Complicated intra-abdominal infection
Dosing
Complicated intra-abdominal infection 1 mg/kg IV infusion over approximately 60 minutes every 12 hours for 4 to 14 days.
Severe hepatic impairment (Child-Pugh C) 1 mg/kg every 12 hours on Day 1, then 1 mg/kg every 24 hours starting on Day 2 for a total duration of 4 to 14 days.
Concomitant strong CYP3A inducer 1.5 mg/kg every 12 hours for a total duration of 4 to 14 days.
Hospital acquired bacterial pneumonia, VABP, Complicated urinary tract infection, Pyelonephritis, Complicated intra-abdominal infection Adults with CLcr >=90 mL/min: 1.25 g (imipenem 500 mg/cilastatin 500 mg/relebactam 250 mg) IV infusion over 30 minutes every 6 hours for 4-14 days; dose reduction required for CLcr <90 mL/min; pediatric patients (>=2 kg): weight- and age-based dosing of 37.5 mg/kg every 6-8 hours IV.
Contraindications
- Known hypersensitivity to eravacycline, tetracycline-class antibacterial drugs, or to any of the excipients
- Severe hypersensitivity (e.g., anaphylaxis) to any component of RECARBRIO
Adverse Reactions
Most common (>=3%) Infusion site reactions, nausea, vomiting
Serious Hypersensitivity reactions, tooth discoloration, inhibition of bone growth, Clostridioides difficile-associated diarrhea, tetracycline class adverse reactions
Most common (>=4%) Anemia, diarrhea, AST increased, ALT increased, hypokalemia, hyponatremia, constipation, pyrexia, rash
Serious Hypersensitivity reactions, seizures and other CNS adverse reactions, Clostridioides difficile-associated diarrhea
Pharmacology
Eravacycline is a fluorocycline antibacterial within the tetracycline class that disrupts bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the incorporation of amino acid residues into elongating peptide chains.
RECARBRIO combines imipenem (a carbapenem that inhibits bacterial cell wall synthesis by binding PBP 2 and PBP 1B), cilastatin (a renal dehydropeptidase inhibitor that prevents renal metabolism of imipenem), and relebactam (a diazabicyclooctane beta-lactamase inhibitor that protects imipenem from degradation by serine beta-lactamases including KPC, AmpC-type PDC, SHV, TEM, and CTX-M enzymes).
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Most Common Insurance
Anthem BCBS
Xerava
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (0/12)
Recarbrio
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Xerava
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Recarbrio
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Xerava
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Recarbrio
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Xerava.
No savings programs available for Recarbrio.
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XeravaView full Xerava profile
RecarbrioView full Recarbrio profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.