| Cystic Fibrosis
Alyftrek vs Symdeko
Side-by-side clinical, coverage, and cost comparison for cystic fibrosis.Deep comparison between: Alyftrek vs Symdeko with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSymdeko has a higher rate of injection site reactions vs Alyftrek based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Symdeko but not Alyftrek, including UnitedHealthcare
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Category
Alyftrek
Symdeko
At A Glance
Oral
Once daily
CFTR modulator (corrector/potentiator)
Oral
Twice daily
CFTR corrector/potentiator
Indications
- Cystic Fibrosis
- Cystic Fibrosis
Dosing
Cystic Fibrosis (ages 6 to <12, weight <40 kg) Three tablets of vanzacaftor 4 mg/tezacaftor 20 mg/deutivacaftor 50 mg once daily orally with fat-containing food.
Cystic Fibrosis (ages 6 to <12, weight >=40 kg; ages >=12) Two tablets of vanzacaftor 10 mg/tezacaftor 50 mg/deutivacaftor 125 mg once daily orally with fat-containing food.
Cystic Fibrosis Adults and patients >=12 years, or patients 6 to <12 years weighing >=30 kg: tezacaftor 100 mg/ivacaftor 150 mg in the morning and ivacaftor 150 mg in the evening, approximately 12 hours apart, with fat-containing food; patients 6 to <12 years weighing <30 kg: tezacaftor 50 mg/ivacaftor 75 mg in the morning and ivacaftor 75 mg in the evening, approximately 12 hours apart, with fat-containing food. Dose adjustment required for moderate or severe hepatic impairment and for co-administration with CYP3A inhibitors.
Contraindications
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Adverse Reactions
Most common (>=5%) Cough, nasopharyngitis, upper respiratory tract infection, headache, oropharyngeal pain, influenza, fatigue, ALT increased, rash, AST increased, sinus congestion
Serious Drug-induced liver injury and liver failure, hypersensitivity reactions including anaphylaxis, intracranial hypertension, neuropsychiatric events including suicidal thoughts and behaviors, cataracts
Postmarketing Intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Most common (>=3%) headache, nausea, sinus congestion, dizziness
Serious transaminase elevations, hypersensitivity reactions including anaphylaxis, intracranial hypertension, neuropsychiatric events including suicidal thoughts and behaviors, cataracts, distal intestinal obstruction syndrome
Postmarketing anaphylaxis, rash, intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Pharmacology
Vanzacaftor and tezacaftor are CFTR correctors that bind to different sites on the CFTR protein to facilitate cellular processing and trafficking of mutant CFTR (including F508del) to the cell surface; deutivacaftor is a CFTR potentiator that enhances channel open probability at the cell surface, resulting in increased CFTR quantity and function.
Tezacaftor/ivacaftor is a CFTR corrector/potentiator combination; tezacaftor facilitates cellular processing and trafficking of mutant CFTR protein (including F508del-CFTR) to the cell surface, while ivacaftor potentiates CFTR channel-open probability, together increasing the quantity and function of CFTR at the cell surface and resulting in increased chloride transport.
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Most Common Insurance
Anthem BCBS
Alyftrek
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Symdeko
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Alyftrek
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (0/8)
Symdeko
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Alyftrek
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Symdeko
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (1/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.