| Cystic Fibrosis
Alyftrek vs Trikafta
Side-by-side clinical, coverage, and cost comparison for cystic fibrosis.Deep comparison between: Alyftrek vs Trikafta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTrikafta has a higher rate of injection site reactions vs Alyftrek based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Trikafta but not Alyftrek, including UnitedHealthcare
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Category
Alyftrek
Trikafta
At A Glance
Oral
Once daily
CFTR modulator (corrector/potentiator)
Oral
Twice daily
CFTR modulator
Indications
- Cystic Fibrosis
- Cystic Fibrosis
Dosing
Cystic Fibrosis (ages 6 to <12, weight <40 kg) Three tablets of vanzacaftor 4 mg/tezacaftor 20 mg/deutivacaftor 50 mg once daily orally with fat-containing food.
Cystic Fibrosis (ages 6 to <12, weight >=40 kg; ages >=12) Two tablets of vanzacaftor 10 mg/tezacaftor 50 mg/deutivacaftor 125 mg once daily orally with fat-containing food.
Cystic Fibrosis Weight-based oral doses (granules for ages 2 to <6, tablets for ages 6+) taken as a morning elexacaftor/tezacaftor/ivacaftor combination dose plus an evening ivacaftor dose approximately 12 hours apart with fat-containing food; dose reduced for moderate hepatic impairment and concomitant CYP3A inhibitors; not for use in severe hepatic impairment.
Contraindications
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Adverse Reactions
Most common (>=5%) Cough, nasopharyngitis, upper respiratory tract infection, headache, oropharyngeal pain, influenza, fatigue, ALT increased, rash, AST increased, sinus congestion
Serious Drug-induced liver injury and liver failure, hypersensitivity reactions including anaphylaxis, intracranial hypertension, neuropsychiatric events including suicidal thoughts and behaviors, cataracts
Postmarketing Intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Most common (>=5%) Headache, upper respiratory tract infection, abdominal pain, diarrhea, rash, alanine aminotransferase increased, nasal congestion, blood creatine phosphokinase increased, aspartate aminotransferase increased, rhinorrhea, rhinitis, influenza, sinusitis, blood bilirubin increased
Serious Drug-induced liver injury and liver failure, hypersensitivity reactions including anaphylaxis, intracranial hypertension, neuropsychiatric events including suicidal thoughts and behaviors, cataracts
Postmarketing Liver injury, fatal liver failure, liver transplantation, anaphylaxis, angioedema, intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Pharmacology
Vanzacaftor and tezacaftor are CFTR correctors that bind to different sites on the CFTR protein to facilitate cellular processing and trafficking of mutant CFTR (including F508del) to the cell surface; deutivacaftor is a CFTR potentiator that enhances channel open probability at the cell surface, resulting in increased CFTR quantity and function.
CFTR modulator triple combination; elexacaftor and tezacaftor are CFTR correctors that bind to different sites on the CFTR protein to facilitate cellular processing and trafficking of mutant CFTR (including F508del-CFTR) to the cell surface, while ivacaftor is a CFTR potentiator that enhances channel open probability at the cell surface, together resulting in increased CFTR quantity and function as measured by CFTR-mediated chloride transport and sweat chloride reduction.
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Most Common Insurance
Anthem BCBS
Alyftrek
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Trikafta
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Alyftrek
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (0/8)
Trikafta
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Alyftrek
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Trikafta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.