| Diabetes Mellitus
Humalog 50/50 vs Novolog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humalog vs Insulin Diluting Medium For Novolog with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsInsulin Diluting Medium For Novolog has a higher rate of injection site reactions vs Humalog based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Insulin Diluting Medium For Novolog but not Humalog, including UnitedHealthcare
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Category
Humalog
Insulin Diluting Medium For Novolog
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
Pre-meal
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously within 15 minutes before a meal into the abdominal wall, thigh, upper arm, or buttocks; typically dosed twice daily, with each dose intended to cover 2 meals or a meal and a snack; individualize dosage based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus Inject SC within 5-10 minutes before a meal into the abdominal area, thigh, buttocks, or upper arm; generally used with an intermediate- or long-acting insulin; may also be administered via continuous SC infusion pump or diluted to 0.05-1 unit/mL for IV infusion; individualize dose based on metabolic needs and blood glucose monitoring results.
Contraindications
- During episodes of hypoglycemia
- Known hypersensitivity to HUMALOG Mix50/50 or any of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to NOVOLOG or one of its excipients
Adverse Reactions
Most common Hypoglycemia
Serious Severe hypersensitivity reactions including anaphylaxis, hypokalemia
Postmarketing Ophthalmologic refraction disorder, worsening of diabetic retinopathy, acute painful peripheral neuropathy, injection site reactions (redness, swelling, itching), lipodystrophy, localized cutaneous amyloidosis, peripheral edema, weight gain, anti-insulin antibody formation
Most common (>=5%) Headache, accidental injury, nausea, diarrhea (type 1 diabetes); hyporeflexia, onychomycosis, sensory disturbance, urinary tract infection, chest pain, skin disorder, abdominal pain, sinusitis (type 2 diabetes)
Serious Severe hypoglycemia, generalized allergy/anaphylaxis, hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, medication errors with insulin substitution, hyperglycemia or hypoglycemia associated with amyloidosis-related injection site changes
Pharmacology
Insulin lispro is a rapid-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; Humalog Mix50/50 combines 50% insulin lispro (rapid-acting) and 50% insulin lispro protamine suspension (intermediate-acting) to provide both rapid onset and prolonged glucose-lowering activity.
Rapid-acting human insulin analog; regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, with peak glucose-lowering effect 1-3 hours after SC injection and duration of action 3-5 hours.
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Most Common Insurance
Anthem BCBS
Humalog
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
Insulin Diluting Medium For Novolog
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Humalog
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Insulin Diluting Medium For Novolog
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Humalog
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (0/3)
Insulin Diluting Medium For Novolog
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humalog.
No savings programs available for Insulin Diluting Medium For Novolog.
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HumalogView full Humalog profile
Insulin Diluting Medium For NovologView full Insulin Diluting Medium For Novolog profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.