| Diabetes Mellitus
Humalog 50/50 vs Lantus
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humalog vs Lantus Solostar with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLantus Solostar has a higher rate of injection site reactions vs Humalog based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lantus Solostar but not Humalog, including UnitedHealthcare
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Category
Humalog
Lantus Solostar
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
Once daily
Long-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously within 15 minutes before a meal into the abdominal wall, thigh, upper arm, or buttocks; typically dosed twice daily, with each dose intended to cover 2 meals or a meal and a snack; individualize dosage based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus, Type 1 Approximately one-third of total daily insulin requirements SC once daily at the same time each day; use short-acting, premeal insulin to satisfy the remainder.
Diabetes Mellitus, Type 2 0.2 units/kg or up to 10 units SC once daily for insulin-naive patients; adjust based on metabolic needs and glucose monitoring results.
Contraindications
- During episodes of hypoglycemia
- Known hypersensitivity to HUMALOG Mix50/50 or any of its excipients
- During episodes of hypoglycemia
- Hypersensitivity to insulin glargine or any excipient in LANTUS
Adverse Reactions
Most common Hypoglycemia
Serious Severe hypersensitivity reactions including anaphylaxis, hypokalemia
Postmarketing Ophthalmologic refraction disorder, worsening of diabetic retinopathy, acute painful peripheral neuropathy, injection site reactions (redness, swelling, itching), lipodystrophy, localized cutaneous amyloidosis, peripheral edema, weight gain, anti-insulin antibody formation
Most common (>=5%) Upper respiratory tract infection, infection (body system unspecified), accidental injury, headache, peripheral edema, retinal vascular disorder, injection site reactions (redness, pain, itching, urticaria, edema, inflammation)
Serious Severe hypoglycemia, systemic hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia, lipodystrophy, weight gain
Postmarketing Medication errors with rapid-acting insulins accidentally administered instead of LANTUS, localized cutaneous amyloidosis at injection site
Pharmacology
Insulin lispro is a rapid-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; Humalog Mix50/50 combines 50% insulin lispro (rapid-acting) and 50% insulin lispro protamine suspension (intermediate-acting) to provide both rapid onset and prolonged glucose-lowering activity.
Insulin glargine is a long-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, providing a relatively constant concentration/time profile over 24 hours with no pronounced peak after subcutaneous injection.
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Most Common Insurance
Anthem BCBS
Humalog
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
Lantus Solostar
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Humalog
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Lantus Solostar
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Humalog
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (0/3)
Lantus Solostar
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humalog.
No savings programs available for Lantus Solostar.
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HumalogView full Humalog profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.