| Diabetes Mellitus
Humalog 50/50 vs Novolog 70/30
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humalog vs Novolog Mix 70/30 with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNovolog Mix 70/30 has a higher rate of injection site reactions vs Humalog based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Novolog Mix 70/30 but not Humalog, including UnitedHealthcare
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Category
Humalog
Novolog Mix 70/30
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
Twice daily
Insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously within 15 minutes before a meal into the abdominal wall, thigh, upper arm, or buttocks; typically dosed twice daily, with each dose intended to cover 2 meals or a meal and a snack; individualize dosage based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus Inject subcutaneously in the abdominal region, buttocks, thigh, or upper arm twice daily within 15 minutes before meal initiation (or after meal initiation for type 2 patients); individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Contraindications
- During episodes of hypoglycemia
- Known hypersensitivity to HUMALOG Mix50/50 or any of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to Novolog Mix 70/30 or one of its excipients
Adverse Reactions
Most common Hypoglycemia
Serious Severe hypersensitivity reactions including anaphylaxis, hypokalemia
Postmarketing Ophthalmologic refraction disorder, worsening of diabetic retinopathy, acute painful peripheral neuropathy, injection site reactions (redness, swelling, itching), lipodystrophy, localized cutaneous amyloidosis, peripheral edema, weight gain, anti-insulin antibody formation
Most common (>=5%) Hypoglycemia, headache, influenza-like symptoms, dyspepsia, back pain, diarrhea, pharyngitis, rhinitis, skeletal pain, upper respiratory tract infection, neuropathy, abdominal pain
Serious Severe hypoglycemia requiring assistance or parenteral glucose/glucagon, anaphylaxis, lipodystrophy, localized cutaneous amyloidosis
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia with repeated injections into areas of amyloidosis, hypoglycemia with sudden change to unaffected injection site, medication errors due to accidental substitution
Pharmacology
Insulin lispro is a rapid-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; Humalog Mix50/50 combines 50% insulin lispro (rapid-acting) and 50% insulin lispro protamine suspension (intermediate-acting) to provide both rapid onset and prolonged glucose-lowering activity.
Biphasic insulin analog consisting of 70% insulin aspart protamine (prolonged absorption) and 30% soluble insulin aspart (rapid absorption); lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and by inhibiting hepatic glucose production.
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Most Common Insurance
Anthem BCBS
Humalog
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
Novolog Mix 70/30
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Humalog
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Novolog Mix 70/30
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Humalog
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (0/3)
Novolog Mix 70/30
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humalog.
No savings programs available for Novolog Mix 70/30.
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HumalogView full Humalog profile
Novolog Mix 70/30View full Novolog Mix 70/30 profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.