| Diabetes Mellitus
Humalog 50/50 vs Humalog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humalog vs Sterile Diluent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSterile Diluent has a higher rate of injection site reactions vs Humalog based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sterile Diluent but not Humalog, including UnitedHealthcare
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Category
Humalog
Sterile Diluent
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
With meals
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously within 15 minutes before a meal into the abdominal wall, thigh, upper arm, or buttocks; typically dosed twice daily, with each dose intended to cover 2 meals or a meal and a snack; individualize dosage based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus Administer subcutaneously within 15 minutes before or immediately after a meal into the abdominal wall, thigh, upper arm, or buttocks; HUMALOG U-100 may also be administered by continuous subcutaneous infusion via insulin pump or by intravenous infusion (diluted, under medical supervision); dosage must be individualized based on route, metabolic needs, and blood glucose monitoring results.
Contraindications
- During episodes of hypoglycemia
- Known hypersensitivity to HUMALOG Mix50/50 or any of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to insulin lispro or any excipient in HUMALOG
Adverse Reactions
Most common Hypoglycemia
Serious Severe hypersensitivity reactions including anaphylaxis, hypokalemia
Postmarketing Ophthalmologic refraction disorder, worsening of diabetic retinopathy, acute painful peripheral neuropathy, injection site reactions (redness, swelling, itching), lipodystrophy, localized cutaneous amyloidosis, peripheral edema, weight gain, anti-insulin antibody formation
Most common (>=5%) Flu syndrome, pharyngitis, rhinitis, headache, pain, increased cough, infection, nausea
Serious Hypoglycemia, hypersensitivity reactions (including anaphylaxis), hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, insulin substitution medication errors, hyperglycemia or hypoglycemia associated with injecting into areas of cutaneous amyloidosis
Pharmacology
Insulin lispro is a rapid-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; Humalog Mix50/50 combines 50% insulin lispro (rapid-acting) and 50% insulin lispro protamine suspension (intermediate-acting) to provide both rapid onset and prolonged glucose-lowering activity.
Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat and inhibiting hepatic glucose production; it is equipotent to human insulin on a molar basis but has a more rapid onset and shorter duration of action.
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Most Common Insurance
Anthem BCBS
Humalog
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
Sterile Diluent
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (8/12)
UnitedHealthcare
Humalog
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Sterile Diluent
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Humalog
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (0/3)
Sterile Diluent
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humalog.
No savings programs available for Sterile Diluent.
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HumalogView full Humalog profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.