| Fibromyalgia
Lyrica vs Savella
Side-by-side clinical, coverage, and cost comparison for fibromyalgia.Deep comparison between: Lyrica vs Savella with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSavella has a higher rate of injection site reactions vs Lyrica based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Savella but not Lyrica, including UnitedHealthcare
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Category
Lyrica
Savella
At A Glance
Oral
2-3 times daily
alpha2-delta calcium channel ligand
Oral
Twice daily
SNRI
Indications
- Peripheral Nervous System Diseases
- Epilepsy
- Fibromyalgia
- chronic pain (diagnosis)
- Fibromyalgia
Dosing
Peripheral Nervous System Diseases Begin at 150 mg/day in 3 divided doses; may increase to max 300 mg/day within 1 week; oral.
chronic pain (diagnosis) PHN: begin at 150 mg/day (75 mg BID or 50 mg TID), max up to 600 mg/day. Spinal cord injury neuropathic pain: begin at 150 mg/day (75 mg BID), max 600 mg/day; oral.
Epilepsy Adults: begin at 150 mg/day in 2 or 3 divided doses, max 600 mg/day. Pediatric >=30 kg: begin 2.5 mg/kg/day, max 10 mg/kg/day. Pediatric <30 kg: begin 3.5 mg/kg/day, max 14 mg/kg/day; oral.
Fibromyalgia Begin at 150 mg/day (75 mg BID); may increase to 300 mg/day within 1 week; max 450 mg/day; oral.
Fibromyalgia Titrate over 7 days to recommended dose of 100 mg/day (50 mg twice daily); may increase to 200 mg/day based on individual response; reduce maintenance dose by 50% to 50 mg/day (25 mg twice daily) in severe renal impairment (CLcr 5-29 mL/min); taper and do not abruptly discontinue after extended use.
Contraindications
- Known hypersensitivity to pregabalin or any of its components
- Concurrent use or use within 5 days of stopping SAVELLA with MAOIs intended to treat psychiatric disorders, or initiation within 14 days of stopping such an MAOI
- Initiation of SAVELLA in patients currently being treated with linezolid or intravenous methylene blue
Adverse Reactions
Most common (>=5%) Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
Serious Angioedema, hypersensitivity, suicidal behavior and ideation, respiratory depression, peripheral edema, weight gain, tumorigenic potential, ophthalmological effects, creatine kinase elevations, decreased platelet count, PR interval prolongation
Postmarketing Headache, nausea, diarrhea, gynecomastia, breast enlargement, bullous pemphigoid, life-threatening respiratory depression with opioids or CNS depressants
Most common (>=5%) Nausea, headache, constipation, dizziness, insomnia, hot flush, hyperhidrosis, vomiting, palpitations, heart rate increased, dry mouth, hypertension
Postmarketing Leukopenia, neutropenia, thrombocytopenia, supraventricular tachycardia, Takotsubo cardiomyopathy, acute pancreatitis, hepatitis, hyponatremia, rhabdomyolysis, convulsions, Stevens Johnson syndrome, hypertensive crisis
Pharmacology
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissues, reducing calcium-dependent release of pro-nociceptive neurotransmitters in the spinal cord and exerting antiseizure effects; it is a structural GABA analogue but does not act directly on GABA receptors, sodium channels, or opiate receptors.
SNRI; milnacipran is a potent inhibitor of neuronal norepinephrine and serotonin reuptake, inhibiting norepinephrine uptake with approximately 3-fold higher potency than serotonin in vitro, without directly affecting dopamine uptake or binding at serotonergic, adrenergic, muscarinic, histamine, dopamine, opiate, benzodiazepine, or GABA receptors.
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Most Common Insurance
Anthem BCBS
Lyrica
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
Savella
- Covered on 5 commercial plans
- PA (3/12) · Step Therapy (3/12) · Qty limit (9/12)
UnitedHealthcare
Lyrica
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Savella
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (2/8) · Qty limit (6/8)
Humana
Lyrica
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Savella
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Lyrica.
No savings programs available for Savella.
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LyricaView full Lyrica profile
SavellaView full Savella profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.