| Gastrointestinal Stromal Tumors
Ayvakit vs Sutent
Side-by-side clinical, coverage, and cost comparison for gastrointestinal stromal tumors.Deep comparison between: Ayvakit vs Sutent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSutent has a higher rate of injection site reactions vs Ayvakit based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sutent but not Ayvakit, including UnitedHealthcare
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Category
Ayvakit
Sutent
At A Glance
Oral
Daily
KIT/PDGFRA kinase inhibitor
Oral
Daily
Multi-targeted RTK inhibitor
Indications
- Gastrointestinal Stromal Tumors
- Aggressive Systemic Mastocytosis
- Indolent Systemic Mastocytosis
- Gastrointestinal Stromal Tumors
- Renal Cell Carcinoma
- Well Differentiated Pancreatic Endocrine Neoplasm
Dosing
Gastrointestinal Stromal Tumors 300 mg orally once daily in patients with PDGFRA exon 18 mutation-positive unresectable or metastatic GIST; continue until disease progression or unacceptable toxicity.
Aggressive Systemic Mastocytosis 200 mg orally once daily; continue until disease progression or unacceptable toxicity.
Indolent Systemic Mastocytosis 25 mg orally once daily.
Gastrointestinal Stromal Tumors, Renal Cell Carcinoma 50 mg orally once daily on Schedule 4/2 (4 weeks on, 2 weeks off); adjuvant RCC limited to a maximum of nine 6-week cycles.
Well Differentiated Pancreatic Endocrine Neoplasm 37.5 mg orally once daily until disease progression or unacceptable toxicity.
Contraindications
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Adverse Reactions
Most common (>=20%) in GIST edema, nausea, fatigue/asthenia, cognitive impairment, vomiting, decreased appetite, diarrhea, increased lacrimation, abdominal pain, constipation, rash, dizziness, hair color changes
Most common (>=20%) in AdvSM edema, diarrhea, nausea, fatigue/asthenia
Most common (>=10%) in ISM eye edema, dizziness, peripheral edema, flushing
Serious intracranial hemorrhage, anemia, pleural effusion, sepsis, gastrointestinal hemorrhage, subdural hematoma, ascites, pneumonia, acute kidney injury, encephalopathy
Most common (>=25%) Fatigue/asthenia, diarrhea, mucositis/stomatitis, nausea, decreased appetite/anorexia, vomiting, abdominal pain, hand-foot syndrome, hypertension, bleeding events, dysgeusia/altered taste, dyspepsia, thrombocytopenia.
Serious Hepatotoxicity, cardiovascular events, QT interval prolongation and Torsade de Pointes, hemorrhagic events, tumor lysis syndrome, thrombotic microangiopathy, proteinuria, dermatologic toxicities, reversible posterior leukoencephalopathy syndrome, thyroid dysfunction, hypoglycemia, osteonecrosis of the jaw, impaired wound healing.
Postmarketing Hemorrhage associated with thrombocytopenia, esophagitis, acalculous cholecystitis, hypersensitivity reactions including angioedema, serious infection, fistula formation, myopathy/rhabdomyolysis, renal impairment/failure, pulmonary embolism, pleural effusion, pyoderma gangrenosum, arterial aneurysms/dissections/rupture, arterial thromboembolic events.
Pharmacology
Avapritinib is a tyrosine kinase inhibitor that targets KIT D816V, PDGFRA, and PDGFRA D842 mutants (IC50s <25 nM), inhibiting autophosphorylation and constitutive activation of these receptors to suppress tumor and mast cell proliferation; other potential targets include wild-type KIT, PDGFRB, and CSFR1.
Sunitinib is a small-molecule inhibitor of multiple receptor tyrosine kinases (RTKs) including PDGFRalpha/beta, VEGFR1/2/3, KIT, FLT3, CSF-1R, and RET, which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer.
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Most Common Insurance
Anthem BCBS
Ayvakit
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
Sutent
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Ayvakit
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (2/8)
Sutent
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Ayvakit
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Sutent
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Gastrointestinal Stromal Tumors (GIST) - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0/fillfill
Sutent Co-Pay Savings ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.