| Glaucoma, Open-Angle
Vyzulta vs Xalatan
Side-by-side clinical, coverage, and cost comparison for glaucoma, open-angle.Deep comparison between: Vyzulta vs Xalatan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXalatan has a higher rate of injection site reactions vs Vyzulta based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xalatan but not Vyzulta, including UnitedHealthcare
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Category
Vyzulta
Xalatan
At A Glance
Topical ophthalmic
Once daily
Prostaglandin analog
Ophthalmic
Once daily
Prostaglandin F2-alpha analogue
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the conjunctival sac of the affected eye(s) once daily in the evening; do not administer more than once daily.
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) once daily in the evening; do not exceed once daily dosing.
Contraindications
—
- Known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product
Adverse Reactions
Most common (>=2%) conjunctival hyperemia, eye irritation, eye pain, instillation site pain
Most common (5-15%) Foreign body sensation, punctate keratitis, stinging, conjunctival hyperemia, blurred vision, itching, burning, increased pigmentation of the iris
Serious Iris pigmentation changes, eyelid skin darkening, eyelash changes, intraocular inflammation (iritis/uveitis), macular edema including cystoid macular edema
Postmarketing Dizziness, headache, toxic epidermal necrolysis, keratitis, corneal edema and erosions, trichiasis, iris cyst, conjunctivitis, pseudopemphigoid of the ocular conjunctiva, asthma, dyspnea, nausea, vomiting, pruritis, herpes keratitis, angina, palpitations, chest pain
Pharmacology
Latanoprostene bunod is a prostaglandin analog and nitric oxide-donating agent that lowers intraocular pressure by increasing aqueous humor outflow through both the trabecular meshwork and uveoscleral routes.
Latanoprost is a prostaglandin F2-alpha analogue that reduces intraocular pressure by increasing uveoscleral outflow of aqueous humor.
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Most Common Insurance
Anthem BCBS
Vyzulta
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (5/12) · Qty limit (9/12)
Xalatan
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Vyzulta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Xalatan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Vyzulta
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Xalatan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Vyzulta.
No savings programs available for Xalatan.
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VyzultaView full Vyzulta profile
XalatanView full Xalatan profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.