| Hemophilia A
Altuviiio vs Eloctate
Side-by-side clinical, coverage, and cost comparison for hemophilia a.Deep comparison between: Altuviiio vs Eloctate with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEloctate has a higher rate of injection site reactions vs Altuviiio based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Eloctate but not Altuviiio, including UnitedHealthcare
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Category
Altuviiio
Eloctate
At A Glance
IV infusion
Once weekly
Recombinant factor VIII
IV infusion
Every 3-5 days
Recombinant Factor VIII Fc fusion protein
Indications
- Hemophilia A
- Hemophilia A
Dosing
Hemophilia A - Routine Prophylaxis 50 IU/kg IV once weekly for adults and children.
Hemophilia A - On-demand (Minor and Moderate Bleeding) Single dose of 50 IU/kg IV; a lower dose of 30 IU/kg may be used for bleeds occurring within 2 to 3 days after a prophylactic dose; additional doses of 30 or 50 IU/kg every 2 to 3 days may be considered.
Hemophilia A - On-demand (Major Bleeding) Single dose of 50 IU/kg IV; additional doses of 30 or 50 IU/kg every 2 to 3 days may be considered.
Hemophilia A - Perioperative (Minor Surgery) Pre-operative: single dose of 50 IU/kg IV; post-operative: an additional dose of 30 or 50 IU/kg after 2 to 3 days may be considered.
Hemophilia A - Perioperative (Major Surgery) Pre-operative: single dose of 50 IU/kg IV; post-operative: additional doses of 30 or 50 IU/kg every 2 to 3 days as clinically needed.
Hemophilia A - Routine Prophylaxis 50 IU/kg IV every 4 days; adjust to 25-65 IU/kg at 3-5 day intervals based on patient response.
Hemophilia A - On-demand (Minor/Moderate Bleeding) 20-30 IU/kg IV, repeat every 24-48 hours until the bleeding episode is resolved.
Hemophilia A - On-demand (Major/Life-threatening Bleeding) 40-50 IU/kg IV, repeat every 12-24 hours until bleeding is resolved (approximately 7-10 days).
Hemophilia A - Perioperative (Minor Surgery) 25-40 IU/kg IV, repeat every 24 hours for at least 1 day until healing is achieved.
Hemophilia A - Perioperative (Major Surgery) 40-60 IU/kg IV preoperatively, then 40-50 IU/kg every 8-24 hours, continuing every 24 hours for at least 7 days post-wound healing.
Contraindications
- Severe hypersensitivity reactions, including anaphylaxis, to ALTUVIIIO or any of its excipients
- Life-threatening hypersensitivity reaction to ELOCTATE or its excipients (sucrose, sodium chloride, L-histidine, calcium chloride, polysorbate 20)
Adverse Reactions
Most common (>10%) Headache, arthralgia (adults and adolescents); pyrexia (children below 12 years)
Serious Thromboembolic events (1% of patients in long-term extension, in patients with pre-existing risk factors)
Postmarketing Factor VIII inhibitor development, hypersensitivity reactions including anaphylaxis
Most common in previously treated patients (>0.5%) Arthralgia, malaise, myalgia, headache, rash
Most common in previously untreated patients (>=1.0%) Factor VIII inhibition, device-related thrombosis, rash papular
Postmarketing Factor VIII inhibitor development, hypersensitivity
Pharmacology
Recombinant FVIII Fc-VWF-XTEN fusion protein that temporarily replaces missing coagulation factor VIII to restore hemostasis in hemophilia A; half-life is extended 3- to 4-fold over standard FVIII products through Fc-FcRn recycling, VWF D'D3 domain shielding from endogenous VWF, and XTEN-mediated reduction in clearance.
ELOCTATE is a recombinant fusion protein that temporarily replaces missing Coagulation Factor VIII needed for effective hemostasis; its Fc region of IgG1 binds to the neonatal Fc receptor (FcRn), delaying lysosomal degradation and prolonging plasma half-life compared to standard recombinant Factor VIII.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Altuviiio
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Eloctate
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Altuviiio
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Eloctate
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Altuviiio
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Eloctate
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited and Acquired Factor Deficiencies - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Inherited and Acquired Factor Deficiencies - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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AltuviiioView full Altuviiio profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.