| HIV Infections
Dovato vs Prezcobix
Side-by-side clinical, coverage, and cost comparison for hiv infections.Deep comparison between: Dovato vs Prezcobix with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsPrezcobix has a higher rate of injection site reactions vs Dovato based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Prezcobix but not Dovato, including UnitedHealthcare
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Category
Dovato
Prezcobix
At A Glance
Oral
Once daily
INSTI/NRTI combination
Oral
Once daily
HIV-1 protease inhibitor
Indications
- HIV Infections
- HIV Infections
Dosing
HIV Infections One tablet (dolutegravir 50 mg/lamivudine 300 mg) orally once daily with or without food; when coadministered with carbamazepine or rifampin, take one additional dolutegravir 50-mg tablet approximately 12 hours after the DOVATO dose.
HIV Infections Adults and pediatric patients >=40 kg: 800 mg/150 mg once daily with food; pediatric patients 25 kg to <40 kg: 675 mg/150 mg once daily with food; pediatric patients 3 years and older, 15 kg to <25 kg: 600 mg/90 mg tablet for oral suspension dispersed in water, once daily with food.
Contraindications
- Prior hypersensitivity reaction to dolutegravir or lamivudine
- Concurrent use of dofetilide due to risk of increased dofetilide plasma concentrations and serious or life-threatening events
- Co-administration with alfuzosin
- Co-administration with carbamazepine, phenobarbital, or phenytoin
- Co-administration with colchicine in patients with renal and/or hepatic impairment
- Co-administration with rifampin
- Co-administration with lurasidone
- Co-administration with pimozide
- Co-administration with dronedarone
- Co-administration with ivabradine
- Co-administration with ranolazine
- Co-administration with ergot derivatives (dihydroergotamine, ergotamine, methylergonovine)
- Co-administration with St. John's wort (Hypericum perforatum)
- Co-administration with elbasvir/grazoprevir
- Co-administration with lomitapide
- Co-administration with lovastatin or simvastatin
- Co-administration with naloxegol
- Co-administration with sildenafil when used for pulmonary arterial hypertension
- Co-administration with orally administered midazolam or triazolam
Adverse Reactions
Most common (>=2%) Headache, nausea, diarrhea, insomnia, fatigue, anxiety, dizziness
Serious Hypersensitivity reactions, hepatotoxicity, lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution syndrome
Postmarketing Body fat redistribution, hyperglycemia, weakness, severe anemia, lactic acidosis and hepatic steatosis, pancreatitis, posttreatment exacerbations of HBV, acute liver failure, anaphylaxis, urticaria, weight gain, arthralgia, CPK elevation, muscle weakness, myalgia, rhabdomyolysis, paresthesia, peripheral neuropathy, alopecia
Most common (>=5%) Diarrhea, nausea, rash, headache, abdominal pain, vomiting
Postmarketing Redistribution of body fat, rhabdomyolysis (with HMG-CoA reductase inhibitors), crystal nephropathy, crystalluria, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms
Pharmacology
DOVATO is a fixed-dose combination of dolutegravir, an HIV-1 integrase strand transfer inhibitor (INSTI) that blocks retroviral DNA integration by binding to the integrase active site, and lamivudine, a nucleoside analogue reverse transcriptase inhibitor (NRTI) that inhibits reverse transcriptase via DNA chain termination after incorporation of the nucleotide analogue.
Darunavir is an HIV-1 protease inhibitor that selectively inhibits cleavage of HIV-1 Gag-Pol polyproteins in infected cells, preventing formation of mature virus particles; cobicistat is a mechanism-based CYP3A inhibitor that increases darunavir systemic exposure without intrinsic antiviral activity.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Dovato
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
Prezcobix
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (1/12) · Qty limit (11/12)
UnitedHealthcare
Dovato
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Prezcobix
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Dovato
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Prezcobix
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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DovatoView full Dovato profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.