| HIV Infections
Dovato vs Stribild
Side-by-side clinical, coverage, and cost comparison for hiv infections.Deep comparison between: Dovato vs Stribild with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsStribild has a higher rate of injection site reactions vs Dovato based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Stribild but not Dovato, including UnitedHealthcare
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Category
Dovato
Stribild
At A Glance
Oral
Once daily
INSTI/NRTI combination
Oral
Once daily
Integrase inhibitor + CYP3A inhibitor + nucleoside/nucleotide analog reverse transcriptase inhibitors
Indications
- HIV Infections
- HIV Infections
Dosing
HIV Infections One tablet (dolutegravir 50 mg/lamivudine 300 mg) orally once daily with or without food; when coadministered with carbamazepine or rifampin, take one additional dolutegravir 50-mg tablet approximately 12 hours after the DOVATO dose.
HIV Infections One tablet (elvitegravir 150 mg, cobicistat 150 mg, emtricitabine 200 mg, tenofovir disoproxil fumarate 300 mg) taken orally once daily with food in adults and pediatric patients 12 years of age and older with body weight at least 35 kg and creatinine clearance >=70 mL/min.
Contraindications
- Prior hypersensitivity reaction to dolutegravir or lamivudine
- Concurrent use of dofetilide due to risk of increased dofetilide plasma concentrations and serious or life-threatening events
- Coadministration with alfuzosin
- Coadministration with carbamazepine, phenobarbital, or phenytoin
- Coadministration with rifampin
- Coadministration with lurasidone or pimozide
- Coadministration with dihydroergotamine, ergotamine, or methylergonovine
- Coadministration with St. John's wort (Hypericum perforatum)
- Coadministration with lomitapide, lovastatin, or simvastatin
- Coadministration with sildenafil when used for pulmonary arterial hypertension
- Coadministration with triazolam or orally administered midazolam
Adverse Reactions
Most common (>=2%) Headache, nausea, diarrhea, insomnia, fatigue, anxiety, dizziness
Serious Hypersensitivity reactions, hepatotoxicity, lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution syndrome
Postmarketing Body fat redistribution, hyperglycemia, weakness, severe anemia, lactic acidosis and hepatic steatosis, pancreatitis, posttreatment exacerbations of HBV, acute liver failure, anaphylaxis, urticaria, weight gain, arthralgia, CPK elevation, muscle weakness, myalgia, rhabdomyolysis, paresthesia, peripheral neuropathy, alopecia
Most common (>=5%) Diarrhea, nausea, headache, fatigue
Serious Severe acute exacerbations of hepatitis B in coinfected patients, new onset or worsening renal impairment, lactic acidosis/severe hepatomegaly with steatosis, bone loss and mineralization defects, immune reconstitution syndrome
Postmarketing Allergic reactions including angioedema, lactic acidosis, hypokalemia, hypophosphatemia, dyspnea, pancreatitis, increased amylase, abdominal pain, hepatic steatosis, hepatitis, increased liver enzymes, rash, rhabdomyolysis, osteomalacia, muscular weakness, myopathy, acute renal failure, renal failure, acute tubular necrosis, Fanconi syndrome, proximal renal tubulopathy, interstitial nephritis, nephrogenic diabetes insipidus, renal insufficiency, increased creatinine, proteinuria, polyuria, asthenia
Pharmacology
DOVATO is a fixed-dose combination of dolutegravir, an HIV-1 integrase strand transfer inhibitor (INSTI) that blocks retroviral DNA integration by binding to the integrase active site, and lamivudine, a nucleoside analogue reverse transcriptase inhibitor (NRTI) that inhibits reverse transcriptase via DNA chain termination after incorporation of the nucleotide analogue.
STRIBILD is a fixed-dose combination of elvitegravir (an integrase strand transfer inhibitor), cobicistat (a CYP3A inhibitor that boosts elvitegravir levels), emtricitabine (a nucleoside reverse transcriptase inhibitor), and tenofovir disoproxil fumarate (a nucleotide reverse transcriptase inhibitor).
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Most Common Insurance
Anthem BCBS
Dovato
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
Stribild
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Dovato
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Stribild
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (3/8) · Qty limit (5/8)
Humana
Dovato
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Stribild
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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DovatoView full Dovato profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.