| HIV Infections
Pifeltro vs Truvada
Side-by-side clinical, coverage, and cost comparison for hiv infections.Deep comparison between: Pifeltro vs Truvada with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTruvada has a higher rate of injection site reactions vs Pifeltro based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Truvada but not Pifeltro, including UnitedHealthcare
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Category
Pifeltro
Truvada
At A Glance
Oral
Once daily
NNRTI
Oral
Once daily
NRTI combination (FTC + TDF)
Indications
- HIV Infections
- HIV Infections
Dosing
HIV Infections One 100 mg tablet orally once daily with or without food in adults and pediatric patients weighing at least 35 kg.
HIV Infections (with rifabutin) One 100 mg tablet orally twice daily (approximately 12 hours apart) for the duration of rifabutin co-administration.
HIV Infections Adults and pediatric patients weighing >=35 kg: one tablet (200 mg FTC/300 mg TDF) once daily orally with or without food; pediatric patients weighing 17 to <35 kg: weight-based lower-strength tablet (100 mg/150 mg, 133 mg/200 mg, or 167 mg/250 mg) once daily; CrCl 30-49 mL/min: one tablet every 48 hours; CrCl <30 mL/min or hemodialysis: not recommended.
HIV-1 Pre-Exposure Prophylaxis HIV-1 uninfected adults and adolescents weighing >=35 kg: one tablet (200 mg FTC/300 mg TDF) once daily orally with or without food; not recommended if CrCl <60 mL/min.
Contraindications
- Co-administration with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin (anticonvulsants)
- Co-administration with enzalutamide (androgen receptor inhibitor)
- Co-administration with rifampin or rifapentine (antimycobacterials)
- Co-administration with mitotane (cytotoxic agent)
- Co-administration with St. John's wort (Hypericum perforatum)
- Unknown or positive HIV-1 status when used for HIV-1 PrEP
Adverse Reactions
Most common (>=5%) Nausea, headache, fatigue, diarrhea, abdominal pain
Postmarketing Stevens-Johnson syndrome/toxic epidermal necrolysis, hepatitis, hepatic enzyme increased
Most common (>=10%) Diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, abnormal dreams, rash
Serious Severe acute exacerbations of hepatitis B, new onset or worsening renal impairment, immune reconstitution syndrome, bone loss and mineralization defects, lactic acidosis/severe hepatomegaly with steatosis
Postmarketing Allergic reaction including angioedema, lactic acidosis, hypokalemia, hypophosphatemia, dyspnea, pancreatitis, hepatic steatosis, hepatitis, rash, rhabdomyolysis, osteomalacia, muscular weakness, myopathy, acute renal failure, Fanconi syndrome, proximal renal tubulopathy, interstitial nephritis, nephrogenic diabetes insipidus, proteinuria, asthenia
Pharmacology
Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 that inhibits viral replication by non-competitive inhibition of HIV-1 reverse transcriptase and does not inhibit human cellular DNA polymerases alpha, beta, or mitochondrial DNA polymerase gamma.
FTC and TDF are both nucleoside analog reverse transcriptase inhibitors (NRTIs); each is converted intracellularly to an active triphosphate form that inhibits HIV-1 reverse transcriptase by competing with natural dNTP substrates and causing chain termination. No antagonism between FTC and TDF has been observed in cell culture combination studies.
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Most Common Insurance
Anthem BCBS
Pifeltro
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (11/12)
Truvada
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Pifeltro
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Truvada
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Humana
Pifeltro
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Truvada
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$0/fillfill
Delstrigo or Pifeltro Savings CouponCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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PifeltroView full Pifeltro profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.