| Homozygous Familial Hypercholesterolemia
Juxtapid vs Lipitor
Side-by-side clinical, coverage, and cost comparison for homozygous familial hypercholesterolemia.Deep comparison between: Juxtapid vs Lipitor with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLipitor has a higher rate of injection site reactions vs Juxtapid based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lipitor but not Juxtapid, including UnitedHealthcare
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Category
Juxtapid
Lipitor
At A Glance
Oral
Daily
MTP inhibitor
Oral
Daily
HMG-CoA reductase inhibitor (statin)
Indications
- Homozygous Familial Hypercholesterolemia
- Myocardial Infarction
- Cerebrovascular accident
- Stable angina
- Diabetes Mellitus, Non-Insulin-Dependent
- Congestive heart failure
- Hyperlipidemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
- Hyperlipoproteinemia Type III
- Hypertriglyceridemia
Dosing
Homozygous Familial Hypercholesterolemia Initiate at 5 mg once daily with water, without food, at least 2 hours after the evening meal; titrate to 10 mg after at least 2 weeks, then at minimum 4-week intervals to 20 mg, 40 mg, and up to 60 mg daily maximum; patients with ESRD on dialysis or mild hepatic impairment (Child-Pugh A) should not exceed 40 mg daily.
Myocardial Infarction, Cerebrovascular accident, Stable angina, Diabetes Mellitus Non-Insulin-Dependent, Congestive heart failure, Hyperlipidemia, Hyperlipoproteinemia Type III, Hypertriglyceridemia 10 or 20 mg once daily starting; range 10-80 mg once daily; patients requiring LDL-C reduction >45% may start at 40 mg once daily; oral.
Familial hypercholesterolemia - heterozygous Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10 mg once daily starting, range 10-20 mg once daily; oral.
Homozygous Familial Hypercholesterolemia Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10-20 mg once daily starting, range 10-80 mg once daily; oral.
Contraindications
- Pregnancy
- Concomitant use of moderate or strong CYP3A4 inhibitors
- Moderate or severe hepatic impairment (Child-Pugh B or C) or active liver disease, including unexplained persistent elevations of serum transaminases
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to atorvastatin or any excipient in Lipitor
Adverse Reactions
Most common (>=28%) Diarrhea, nausea, vomiting, dyspepsia, abdominal pain
Serious Hepatotoxicity, increased ALT
Postmarketing Myalgia, alopecia
Most common (>=2%) Nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal pain, muscle spasms, myalgia, insomnia, pharyngolaryngeal pain
Serious Myopathy and rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, increases in HbA1c and fasting serum glucose
Postmarketing Pancreatitis, fatigue, fatal and non-fatal hepatic failure, anaphylaxis, tendon rupture, rhabdomyolysis, myositis, dizziness, peripheral neuropathy, cognitive impairment, myasthenia gravis exacerbation, depression, interstitial lung disease, angioneurotic edema, bullous rashes
Pharmacology
MTP inhibitor; lomitapide directly binds and inhibits microsomal triglyceride transfer protein (MTP) in the endoplasmic reticulum, preventing assembly of apo B-containing lipoproteins in enterocytes and hepatocytes, thereby inhibiting synthesis of chylomicrons and VLDL and reducing plasma LDL-C.
Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of cholesterol; it lowers plasma LDL cholesterol and lipoprotein levels by inhibiting hepatic cholesterol synthesis and upregulating LDL receptor expression on hepatic cell surfaces.
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Most Common Insurance
Anthem BCBS
Juxtapid
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Lipitor
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (1/12)
UnitedHealthcare
Juxtapid
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (5/8) · Qty limit (0/8)
Lipitor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Juxtapid
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Lipitor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Hypercholesterolemia - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Lipitor.
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JuxtapidView full Juxtapid profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.