| Hypertensive disease
Benicar HCT vs Nexiclon XR
Side-by-side clinical, coverage, and cost comparison for hypertensive disease.Deep comparison between: Benicar Hct vs Nexiclon Xr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexiclon Xr has a higher rate of injection site reactions vs Benicar Hct based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexiclon Xr but not Benicar Hct, including UnitedHealthcare
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Category
Benicar Hct
Nexiclon Xr
At A Glance
Oral
Daily
ARB / thiazide diuretic
Oral
Once daily
Centrally active alpha-adrenergic agonist
Indications
- Hypertensive disease
- Hypertensive disease
Dosing
Hypertensive disease Starting dose 40/12.5 mg or 20/12.5 mg once daily depending on prior monotherapy; titrate up to 40/25 mg if needed.
Hypertensive disease Initiate at 0.17 mg once daily at bedtime; titrate by 0.09 mg once daily at weekly intervals as needed; usual range 0.17-0.52 mg once daily.
Renal Impairment End-stage kidney disease on dialysis: start at 0.09 mg/day and titrate slowly; moderate to severe impairment not on dialysis: initiate at standard dose and titrate slowly with monitoring for bradycardia, sedation, and hypotension.
Contraindications
- Hypersensitivity to any component of BENICAR HCT
- Anuria
- Coadministration with aliskiren in patients with diabetes
- Known hypersensitivity to clonidine
Adverse Reactions
Most common (>2%) Dizziness, upper respiratory infection, hyperuricemia, nausea
Serious Hypotension, impaired renal function, hypersensitivity reactions, electrolyte and metabolic imbalances, acute myopia and secondary angle-closure glaucoma, systemic lupus erythematosus, sprue-like enteropathy
Postmarketing Asthenia, vomiting, hyperkalemia, rhabdomyolysis, alopecia, pruritus
Most common (>=10%) Dry mouth, drowsiness, dizziness, constipation, sedation
Serious Withdrawal syndrome, allergic reactions
Pharmacology
Olmesartan medoxomil selectively blocks angiotensin II binding to the AT1 receptor in vascular smooth muscle, inhibiting vasoconstriction independent of angiotensin II synthesis pathways; hydrochlorothiazide is a thiazide diuretic that directly increases renal excretion of sodium and chloride, reducing plasma volume to lower blood pressure.
Clonidine stimulates alpha-adrenoreceptors in the brain stem, reducing sympathetic outflow from the CNS and decreasing peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Benicar Hct
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (10/12)
Nexiclon Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Benicar Hct
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Nexiclon Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Benicar Hct
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Nexiclon Xr
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (1/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Benicar Hct.
No savings programs available for Nexiclon Xr.
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Benicar HctView full Benicar Hct profile
Nexiclon XrView full Nexiclon Xr profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.