| Hypertensive disease
Bystolic vs Nexiclon XR
Side-by-side clinical, coverage, and cost comparison for hypertensive disease.Deep comparison between: Bystolic vs Nexiclon Xr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexiclon Xr has a higher rate of injection site reactions vs Bystolic based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexiclon Xr but not Bystolic, including UnitedHealthcare
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Category
Bystolic
Nexiclon Xr
At A Glance
Oral
Daily
Selective beta-1 blocker
Oral
Once daily
Centrally active alpha-adrenergic agonist
Indications
- Hypertensive disease
- Hypertensive disease
Dosing
Hypertensive disease Start at 5 mg once daily, with or without food; increase at 2-week intervals up to 40 mg. In severe renal impairment (ClCr <30 mL/min), start at 2.5 mg once daily. In moderate hepatic impairment (Child-Pugh Class B), start at 2.5 mg once daily.
Hypertensive disease Initiate at 0.17 mg once daily at bedtime; titrate by 0.09 mg once daily at weekly intervals as needed; usual range 0.17-0.52 mg once daily.
Renal Impairment End-stage kidney disease on dialysis: start at 0.09 mg/day and titrate slowly; moderate to severe impairment not on dialysis: initiate at standard dose and titrate slowly with monitoring for bradycardia, sedation, and hypotension.
Contraindications
- Severe bradycardia
- Heart block greater than first degree
- Cardiogenic shock
- Decompensated cardiac failure
- Sick sinus syndrome (unless a permanent pacemaker is in place)
- Severe hepatic impairment (Child-Pugh >B)
- Hypersensitivity to any component of this product
- Known hypersensitivity to clonidine
Adverse Reactions
Most common (>=1%) Headache, fatigue, diarrhea, nausea, dizziness, bradycardia, chest pain, peripheral edema, insomnia, dyspnea, rash
Postmarketing Abnormal hepatic function, acute pulmonary edema, acute renal failure, atrioventricular block (second and third degree), bronchospasm, erectile dysfunction, hypersensitivity (urticaria, allergic vasculitis, angioedema), hypotension, myocardial infarction, pruritus, psoriasis, Raynaud's phenomenon, peripheral ischemia/claudication, somnolence, syncope, thrombocytopenia, vertigo, vomiting
Most common (>=10%) Dry mouth, drowsiness, dizziness, constipation, sedation
Serious Withdrawal syndrome, allergic reactions
Pharmacology
Nebivolol is a beta-adrenergic receptor blocking agent; at doses <=10 mg in extensive metabolizers it is preferentially beta1-selective, while in poor metabolizers or at higher doses it inhibits both beta1- and beta2-adrenergic receptors, lacking intrinsic sympathomimetic and membrane-stabilizing activity at therapeutically relevant concentrations.
Clonidine stimulates alpha-adrenoreceptors in the brain stem, reducing sympathetic outflow from the CNS and decreasing peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Bystolic
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (4/12) · Qty limit (1/12)
Nexiclon Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Bystolic
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Nexiclon Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Bystolic
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Nexiclon Xr
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (1/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Bystolic.
No savings programs available for Nexiclon Xr.
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BystolicView full Bystolic profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.