| Hypertensive disease
Katerzia vs Nexiclon XR
Side-by-side clinical, coverage, and cost comparison for hypertensive disease.Deep comparison between: Katerzia vs Nexiclon Xr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexiclon Xr has a higher rate of injection site reactions vs Katerzia based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexiclon Xr but not Katerzia, including UnitedHealthcare
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Category
Katerzia
Nexiclon Xr
At A Glance
Oral
Daily
Calcium channel blocker
Oral
Once daily
Centrally active alpha-adrenergic agonist
Indications
- Hypertensive disease
- Stable angina
- Angina Pectoris, Variant
- Coronary Artery Disease
- Hypertensive disease
Dosing
Hypertensive disease (adults) 5 mg orally once daily (max 10 mg); start 2.5 mg in small, fragile, elderly patients, or those with hepatic insufficiency.
Hypertensive disease (pediatric, ages 6-17) 2.5-5 mg orally once daily; doses >5 mg have not been studied in pediatric patients.
Stable angina, Angina Pectoris, Variant 5-10 mg orally once daily; lower dose suggested in elderly and patients with hepatic insufficiency; most patients require 10 mg.
Coronary Artery Disease 5-10 mg orally once daily; majority of patients required 10 mg in clinical studies.
Hypertensive disease Initiate at 0.17 mg once daily at bedtime; titrate by 0.09 mg once daily at weekly intervals as needed; usual range 0.17-0.52 mg once daily.
Renal Impairment End-stage kidney disease on dialysis: start at 0.09 mg/day and titrate slowly; moderate to severe impairment not on dialysis: initiate at standard dose and titrate slowly with monitoring for bradycardia, sedation, and hypotension.
Contraindications
- Known sensitivity to amlodipine
- Known hypersensitivity to clonidine
Adverse Reactions
Most common (>1%) edema, dizziness, flushing, palpitation, fatigue, nausea, abdominal pain, somnolence
Postmarketing gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder
Most common (>=10%) Dry mouth, drowsiness, dizziness, constipation, sedation
Serious Withdrawal syndrome, allergic reactions
Pharmacology
Amlodipine is a dihydropyridine calcium channel blocker that inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, causing peripheral arterial vasodilation, reduction in peripheral vascular resistance, and reduction in blood pressure.
Clonidine stimulates alpha-adrenoreceptors in the brain stem, reducing sympathetic outflow from the CNS and decreasing peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
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Most Common Insurance
Anthem BCBS
Katerzia
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (1/12) · Qty limit (8/12)
Nexiclon Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Katerzia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Nexiclon Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Katerzia
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Nexiclon Xr
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (1/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Katerzia.
No savings programs available for Nexiclon Xr.
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KaterziaView full Katerzia profile
Nexiclon XrView full Nexiclon Xr profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.