| Hypoglycemia
Gvoke HypoPen vs Baqsimi
Side-by-side clinical, coverage, and cost comparison for hypoglycemia.Deep comparison between: Gvoke Hypopen vs Baqsimi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsBaqsimi has a higher rate of injection site reactions vs Gvoke Hypopen based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Baqsimi but not Gvoke Hypopen, including UnitedHealthcare
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Category
Gvoke Hypopen
Baqsimi
At A Glance
SC injection
Single dose
Glucagon receptor agonist
Intranasal
As needed
Antihypoglycemic agent
Indications
- Hypoglycemia
- Hypoglycemia
Dosing
Hypoglycemia (adults and pediatric patients >=12 years) 1 mg SC injection into lower abdomen, outer thigh, or outer upper arm; may repeat 1 mg from a new device after 15 minutes if no response while awaiting emergency assistance.
Hypoglycemia (pediatric patients 2 to <12 years, <45 kg) 0.5 mg SC injection into lower abdomen, outer thigh, or outer upper arm; may repeat 0.5 mg from a new device after 15 minutes if no response while awaiting emergency assistance.
Hypoglycemia (pediatric patients 2 to <12 years, >=45 kg) 1 mg SC injection into lower abdomen, outer thigh, or outer upper arm; may repeat 1 mg from a new device after 15 minutes if no response while awaiting emergency assistance.
Diagnostic aid (stomach, duodenal bulb, duodenum, small bowel) 0.2 mg to 0.5 mg IV slow push (GVOKE VialDx only), diluted to 0.45 mg/mL with 0.9% Sodium Chloride Injection, administered under medical supervision.
Diagnostic aid (colon) 0.5 mg to 0.75 mg IV slow push (GVOKE VialDx only), diluted to 0.45 mg/mL with 0.9% Sodium Chloride Injection, administered under medical supervision.
Hypoglycemia 3 mg as one intranasal actuation into one nostril; if no response after 15 minutes, an additional 3 mg dose from a new device may be administered while waiting for emergency assistance.
Contraindications
- Pheochromocytoma, due to risk of substantial increase in blood pressure
- Insulinoma, due to risk of hypoglycemia
- Prior hypersensitivity reaction to glucagon or any excipient in GVOKE or GVOKE VialDx
- Glucagonoma (GVOKE VialDx only), due to risk of hypoglycemia
- Pheochromocytoma, due to risk of substantial increase in blood pressure
- Insulinoma, due to risk of hypoglycemia
- Prior hypersensitivity reaction to glucagon or any excipient in BAQSIMI
Adverse Reactions
Most common (>=2%) Nausea, vomiting, injection site edema, headache (adults); nausea, hypoglycemia, vomiting, headache, hyperglycemia, abdominal pain, injection site discomfort, urticaria (pediatric patients).
Serious Substantial increase in blood pressure in patients with pheochromocytoma, hypoglycemia in patients with insulinoma, serious hypersensitivity reactions including anaphylactic shock, lack of efficacy in patients with decreased hepatic glycogen, necrolytic migratory erythema, hyperglycemia with IV diagnostic use in patients with diabetes mellitus, blood pressure and heart rate increases with IV diagnostic use in patients with cardiac disease, hypoglycemia in patients with glucagonoma with IV diagnostic use.
Postmarketing Necrolytic migratory erythema with continuous glucagon infusion, hypoglycemia and hypoglycemic coma, hypoglycemia in patients taking indomethacin.
Most common (>=2%) Nausea, headache, vomiting, upper respiratory tract irritation (nasal discomfort, nasal congestion, sneezing, cough, epistaxis)
Serious Substantial increase in blood pressure in pheochromocytoma patients, hypoglycemia in insulinoma patients, serious hypersensitivity reactions including anaphylactic shock, lack of efficacy in patients with decreased hepatic glycogen
Other Dysgeusia, pruritus, tachycardia, hypertension, nasal pruritus, throat irritation, parosmia
Pharmacology
Glucagon activates hepatic glucagon receptors, stimulating glycogen breakdown and glucose release from the liver to raise blood glucose concentration; it also relaxes smooth muscle of the stomach, duodenum, small bowel, and colon.
Glucagon activates hepatic glucagon receptors, stimulating glycogen breakdown and release of glucose from the liver; adequate hepatic glycogen stores are required for the antihypoglycemic effect.
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Most Common Insurance
Anthem BCBS
Gvoke Hypopen
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (10/12)
Baqsimi
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Gvoke Hypopen
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Baqsimi
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Gvoke Hypopen
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (0/3)
Baqsimi
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Gvoke Hypopen.
No savings programs available for Baqsimi.
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Gvoke HypopenView full Gvoke Hypopen profile
BaqsimiView full Baqsimi profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.