| Hypogonadotropic hypogonadism
Natesto vs Tlando
Side-by-side clinical, coverage, and cost comparison for hypogonadotropic hypogonadism.Deep comparison between: Natesto vs Tlando with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTlando has a higher rate of injection site reactions vs Natesto based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tlando but not Natesto, including UnitedHealthcare
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Category
Natesto
Tlando
At A Glance
Intranasal
Three times daily
Androgen
Oral
Twice daily
Androgen
Indications
- Primary hypogonadism
- Hypogonadotropic hypogonadism
- Primary hypogonadism
- Hypogonadotropic hypogonadism
Dosing
Primary hypogonadism, Hypogonadotropic hypogonadism 11 mg (2 pump actuations, 1 per nostril) administered intranasally three times daily (morning, afternoon, and evening, 6-8 hours apart) for a total daily dose of 33 mg; discontinue if total testosterone consistently exceeds 1050 ng/dL.
Primary hypogonadism, Hypogonadotropic hypogonadism 225 mg (two 112.5 mg capsules) orally twice daily with food, once in the morning and once in the evening; monitor serum testosterone 8-9 hours after morning dose at 3-4 weeks and periodically thereafter.
Contraindications
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Women who are or may become pregnant
- Women who are breast-feeding
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Pregnancy (testosterone can cause virilization of the female fetus)
- Known hypersensitivity to testosterone undecanoate or any of TLANDO's ingredients
Adverse Reactions
Most common (>=3%) PSA increased, headache, rhinorrhea, epistaxis, nasal discomfort, nasopharyngitis, bronchitis, upper respiratory tract infection, sinusitis, nasal scab
Postmarketing Myocardial infarction, stroke, venous thromboembolism
Most common (>=2%) increased blood prolactin, hypertension, increased hematocrit, upper respiratory tract infection, weight increased, headache, musculoskeletal pain
Serious polycythemia, venous thromboembolism, worsening of benign prostatic hyperplasia and potential risk of prostate cancer, blood pressure increases, hepatic adverse effects, edema, sleep apnea, gynecomastia, lipid changes, hypercalcemia
Postmarketing myocardial infarction, stroke, venous thromboembolism
Pharmacology
Testosterone is an endogenous androgen responsible for the normal growth and development of male sex organs and maintenance of secondary sex characteristics; Natesto delivers physiologic amounts of testosterone intranasally to restore deficient endogenous testosterone concentrations in hypogonadal men.
Androgen; testosterone undecanoate is a lipophilic ester of testosterone that, after oral absorption primarily via the lymphatic system (bypassing first-pass hepatic metabolism), is converted to testosterone, which is responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics.
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Most Common Insurance
Anthem BCBS
Natesto
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
Tlando
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
Natesto
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Tlando
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Natesto
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Tlando
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Natesto.
No savings programs available for Tlando.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.