| Hypogonadotropic hypogonadism
Tlando vs Natesto
Side-by-side clinical, coverage, and cost comparison for hypogonadotropic hypogonadism.Deep comparison between: Tlando vs Natesto with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNatesto has a higher rate of injection site reactions vs Tlando based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Natesto but not Tlando, including UnitedHealthcare
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Category
Tlando
Natesto
At A Glance
Oral
Twice daily
Androgen
Intranasal
Three times daily
Androgen
Indications
- Primary hypogonadism
- Hypogonadotropic hypogonadism
- Primary hypogonadism
- Hypogonadotropic hypogonadism
Dosing
Primary hypogonadism, Hypogonadotropic hypogonadism 225 mg (two 112.5 mg capsules) orally twice daily with food, once in the morning and once in the evening; monitor serum testosterone 8-9 hours after morning dose at 3-4 weeks and periodically thereafter.
Primary hypogonadism, Hypogonadotropic hypogonadism 11 mg (2 pump actuations, 1 per nostril) administered intranasally three times daily (morning, afternoon, and evening, 6-8 hours apart) for a total daily dose of 33 mg; discontinue if total testosterone consistently exceeds 1050 ng/dL.
Contraindications
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Pregnancy (testosterone can cause virilization of the female fetus)
- Known hypersensitivity to testosterone undecanoate or any of TLANDO's ingredients
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Women who are or may become pregnant
- Women who are breast-feeding
Adverse Reactions
Most common (>=2%) increased blood prolactin, hypertension, increased hematocrit, upper respiratory tract infection, weight increased, headache, musculoskeletal pain
Serious polycythemia, venous thromboembolism, worsening of benign prostatic hyperplasia and potential risk of prostate cancer, blood pressure increases, hepatic adverse effects, edema, sleep apnea, gynecomastia, lipid changes, hypercalcemia
Postmarketing myocardial infarction, stroke, venous thromboembolism
Most common (>=3%) PSA increased, headache, rhinorrhea, epistaxis, nasal discomfort, nasopharyngitis, bronchitis, upper respiratory tract infection, sinusitis, nasal scab
Postmarketing Myocardial infarction, stroke, venous thromboembolism
Pharmacology
Androgen; testosterone undecanoate is a lipophilic ester of testosterone that, after oral absorption primarily via the lymphatic system (bypassing first-pass hepatic metabolism), is converted to testosterone, which is responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics.
Testosterone is an endogenous androgen responsible for the normal growth and development of male sex organs and maintenance of secondary sex characteristics; Natesto delivers physiologic amounts of testosterone intranasally to restore deficient endogenous testosterone concentrations in hypogonadal men.
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Most Common Insurance
Anthem BCBS
Tlando
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (10/12)
Natesto
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Tlando
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Natesto
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Tlando
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Natesto
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Tlando.
No savings programs available for Natesto.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.