| Immune thrombocytopenic purpura
Gammaked vs Rhophylac
Side-by-side clinical, coverage, and cost comparison for immune thrombocytopenic purpura.Deep comparison between: Gammaked vs Rhophylac with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRhophylac has a higher rate of injection site reactions vs Gammaked based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rhophylac but not Gammaked, including UnitedHealthcare
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Category
Gammaked
Rhophylac
At A Glance
IV infusion
Immune globulin
IV or IM injection
Single dose
Rh(D) immune globulin
Indications
- Primary immune deficiency disorder
- Immune thrombocytopenic purpura
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
- Congenital agammaglobulinemia
- Common Variable Immunodeficiency
- X-linked agammaglobulinemia
- Wiskott-Aldrich Syndrome
- Severe Combined Immunodeficiency
- Rh Isoimmunization
- Immune thrombocytopenic purpura
Dosing
Primary immune deficiency disorder IV: 300-600 mg/kg every 3-4 weeks; SC (PI only): individualized weekly dose calculated as previous IGIV dose (g) x 1.37 divided by number of weeks between IV doses.
Immune thrombocytopenic purpura IV only: total dose 2 g/kg given as 1 g/kg on two consecutive days or 0.4 g/kg on five consecutive days; do not administer subcutaneously.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating IV only: loading dose 2 g/kg over two to four consecutive days; maintenance 1 g/kg every 3 weeks (or 0.5 g/kg on two consecutive days every 3 weeks).
Rh Isoimmunization 300 mcg (1500 IU) IV or IM injection; routine antepartum prophylaxis at week 28-30 of pregnancy; postpartum and obstetric complication doses within 72 hours of event; for excessive fetomaternal hemorrhage (>15 mL fetal RBCs), 300 mcg plus 20 mcg per mL fetal RBCs in excess of 15 mL; for incompatible transfusions, 20 mcg per 2 mL Rh(D)-positive whole blood within 72 hours of exposure.
Immune thrombocytopenic purpura 50 mcg per kg body weight by IV route only, administered at a rate of 2 mL per 15 to 60 seconds.
Contraindications
- Previous anaphylactic or severe systemic reaction to human immune globulin
- IgA deficiency with antibodies against IgA and history of hypersensitivity reaction
- Previous anaphylactic or severe systemic reaction to human immune globulin
- IgA deficiency with antibodies to IgA and history of hypersensitivity to RHOPHYLAC or any of its components
- Newborn infant of a mother who received RHOPHYLAC postpartum
Adverse Reactions
Most common (>=5%) PI (IV): cough, rhinitis, pharyngitis, headache, asthma, nausea, fever, diarrhea, sinusitis; PI (SC): local infusion site reactions, fatigue, headache, upper respiratory tract infection, arthralgia, diarrhea, nausea, sinusitis, bronchitis, depression, allergic dermatitis, erythema, migraine, myalgia, viral infection, pyrexia; ITP: headache, ecchymosis, vomiting, fever, nausea, rash, abdominal pain, back pain, dyspepsia; CIDP: headache, pyrexia, hypertension, chills, rash, nausea, arthralgia, asthenia
Serious Pulmonary embolism (CIDP), exacerbation of autoimmune pure red cell aplasia (PI), hemolytic anemia
Postmarketing Anaphylaxis, tachycardia, acute renal dysfunction/failure, ARDS, TRALI, pulmonary edema, cardiac arrest, thromboembolism, coma, seizures, aseptic meningitis, Stevens-Johnson syndrome, pancytopenia, hemolytic anemia, hepatic dysfunction
Most common - Rh Isoimmunization (>=0.5%) Nausea, dizziness, headache, injection-site pain, malaise
Most common - Immune thrombocytopenic purpura (>14%) Chills, pyrexia/increased body temperature, increased blood bilirubin, headache
Serious Intravascular hemolysis, clinically compromising anemia, acute renal insufficiency, DIC (observed in ITP treatment)
Postmarketing Hypersensitivity reactions including anaphylactic shock, headache, dizziness, vertigo, hypotension, tachycardia, dyspnea, nausea, vomiting, rash, erythema, pruritus, chills, pyrexia, malaise, diarrhea, back pain
Pharmacology
GAMMAKED is an immune globulin that supplies a broad spectrum of opsonic and neutralizing IgG antibodies against bacterial, viral, parasitic, and mycoplasmal agents and their toxins; the precise mechanism of action in ITP and CIDP has not been fully elucidated.
Rh(D) immune globulin (anti-D) that suppresses immunization to Rh(D)-positive RBCs by accelerating their clearance; in ITP, forms Rh(D) immune globulin-RBC complexes preferentially removed by the reticuloendothelial system, causing Fc receptor blockade that spares antibody-coated platelets.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Gammaked
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Rhophylac
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (10/12)
UnitedHealthcare
Gammaked
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Rhophylac
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Gammaked
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (0/3)
Rhophylac
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Gammaked.
Cost estimate not availableAssistance Fund: Thrombocytopenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.