| Immune thrombocytopenic purpura
Tavalisse vs Rhophylac
Side-by-side clinical, coverage, and cost comparison for immune thrombocytopenic purpura.Deep comparison between: Tavalisse vs Rhophylac with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRhophylac has a higher rate of injection site reactions vs Tavalisse based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rhophylac but not Tavalisse, including UnitedHealthcare
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Category
Tavalisse
Rhophylac
At A Glance
Oral
Twice daily
SYK inhibitor
IV or IM injection
Single dose
Rh(D) immune globulin
Indications
- Immune thrombocytopenic purpura
- Rh Isoimmunization
- Immune thrombocytopenic purpura
Dosing
Immune thrombocytopenic purpura Initiate at 100 mg orally twice daily; after 4 weeks, increase to 150 mg twice daily if platelet count has not reached at least 50 x 10 9 /L; use the lowest dose to maintain platelet count at least 50 x 10 9 /L; discontinue after 12 weeks if platelet count does not increase sufficiently to avoid clinically important bleeding.
Rh Isoimmunization 300 mcg (1500 IU) IV or IM injection; routine antepartum prophylaxis at week 28-30 of pregnancy; postpartum and obstetric complication doses within 72 hours of event; for excessive fetomaternal hemorrhage (>15 mL fetal RBCs), 300 mcg plus 20 mcg per mL fetal RBCs in excess of 15 mL; for incompatible transfusions, 20 mcg per 2 mL Rh(D)-positive whole blood within 72 hours of exposure.
Immune thrombocytopenic purpura 50 mcg per kg body weight by IV route only, administered at a rate of 2 mL per 15 to 60 seconds.
Contraindications
—
- Previous anaphylactic or severe systemic reaction to human immune globulin
- IgA deficiency with antibodies to IgA and history of hypersensitivity to RHOPHYLAC or any of its components
- Newborn infant of a mother who received RHOPHYLAC postpartum
Adverse Reactions
Most common (>=5%) Diarrhea, hypertension, nausea, dizziness, ALT increased, AST increased, respiratory infection, rash, abdominal pain, fatigue, chest pain, neutropenia
Serious Febrile neutropenia, diarrhea, pneumonia, hypertensive crisis
Most common - Rh Isoimmunization (>=0.5%) Nausea, dizziness, headache, injection-site pain, malaise
Most common - Immune thrombocytopenic purpura (>14%) Chills, pyrexia/increased body temperature, increased blood bilirubin, headache
Serious Intravascular hemolysis, clinically compromising anemia, acute renal insufficiency, DIC (observed in ITP treatment)
Postmarketing Hypersensitivity reactions including anaphylactic shock, headache, dizziness, vertigo, hypotension, tachycardia, dyspnea, nausea, vomiting, rash, erythema, pruritus, chills, pyrexia, malaise, diarrhea, back pain
Pharmacology
Fostamatinib is a tyrosine kinase inhibitor with demonstrated activity against spleen tyrosine kinase (SYK); its major active metabolite R406 inhibits signal transduction of Fc-activating receptors and B-cell receptor, reducing antibody-mediated destruction of platelets.
Rh(D) immune globulin (anti-D) that suppresses immunization to Rh(D)-positive RBCs by accelerating their clearance; in ITP, forms Rh(D) immune globulin-RBC complexes preferentially removed by the reticuloendothelial system, causing Fc receptor blockade that spares antibody-coated platelets.
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Most Common Insurance
Anthem BCBS
Tavalisse
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Rhophylac
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (10/12)
UnitedHealthcare
Tavalisse
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (5/8)
Rhophylac
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Tavalisse
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Rhophylac
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$15/fillfill
Tavalisse Copay AssistanceCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Thrombocytopenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.