| Infection caused by Helicobacter pylori
Aciphex vs Talicia
Side-by-side clinical, coverage, and cost comparison for infection caused by helicobacter pylori.Deep comparison between: Aciphex vs Talicia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTalicia has a higher rate of injection site reactions vs Aciphex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Talicia but not Aciphex, including UnitedHealthcare
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Category
Aciphex
Talicia
At A Glance
Oral
Once daily
Proton pump inhibitor
Oral
Three times daily
Antibacterial/PPI combination
Indications
- Gastroesophageal reflux disease
- Duodenal Ulcer
- Infection caused by Helicobacter pylori
- Zollinger-Ellison syndrome
- Infection caused by Helicobacter pylori
Dosing
Gastroesophageal reflux disease 20 mg once daily orally; healing 4-8 weeks (additional 8 weeks if not healed), maintenance ongoing (studies up to 12 months), symptomatic adults up to 4 weeks, adolescents 12+ years up to 8 weeks.
Duodenal Ulcer 20 mg once daily orally after the morning meal for up to 4 weeks.
Infection caused by Helicobacter pylori ACIPHEX 20 mg plus amoxicillin 1000 mg plus clarithromycin 500 mg, all twice daily with morning and evening meals for 7 days.
Zollinger-Ellison syndrome Starting dose 60 mg once daily orally, adjusted to patient needs; doses up to 100 mg once daily or 60 mg twice daily; treat as long as clinically indicated.
Infection caused by Helicobacter pylori Four capsules (rifabutin 50 mg, amoxicillin 1,000 mg, omeprazole 40 mg) three times daily (at least 4 hours apart) with food for 14 days; swallow capsules whole with a full glass of water; do not crush, chew, or take with alcohol.
Contraindications
- Known hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with rilpivirine-containing products
- Known hypersensitivity to amoxicillin or other beta-lactam antibacterials (penicillins, cephalosporins), omeprazole or other benzimidazoles (PPIs, anthelmintics), rifabutin or any other rifamycins, or any other component of TALICIA
- Concomitant use with rilpivirine-containing products
- Concomitant use with delavirdine
- Concomitant use with voriconazole
Adverse Reactions
Most common (>=2%) Pain, pharyngitis, flatulence, infection, constipation (adults); headache, diarrhea, nausea, vomiting, abdominal pain (adolescents); diarrhea, taste perversion (H. pylori triple therapy)
Serious Acute tubulointerstitial nephritis, Clostridium difficile-associated diarrhea, bone fracture, cutaneous and systemic lupus erythematosus, cyanocobalamin deficiency, hypomagnesemia, fundic gland polyps
Postmarketing Agranulocytosis, hemolytic anemia, pancytopenia, thrombocytopenia, anaphylaxis, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AGEP, rhabdomyolysis, interstitial nephritis, interstitial pneumonia, jaundice, sudden death, severe dermatologic reactions
Most common (>=1%) Diarrhea, headache, nausea, abdominal pain, chromaturia, rash, dyspepsia, vomiting, oropharyngeal pain, vulvovaginal candidiasis
Serious Hypersensitivity reactions, severe cutaneous adverse reactions, drug-induced enterocolitis syndrome, Clostridioides difficile-associated diarrhea, acute tubulointerstitial nephritis, cutaneous and systemic lupus erythematosus, rash in patients with mononucleosis, uveitis
Postmarketing Reported for individual components: pancreatitis, hepatic failure, agranulocytosis, pancytopenia, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AGEP, linear IgA bullous dermatosis, lymphopenia (see prescribing information for full list by component)
Pharmacology
Rabeprazole is a substituted benzimidazole proton-pump inhibitor that suppresses gastric acid secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of the parietal cell, blocking the final step of acid production; in parietal cells it is protonated, accumulates, and is transformed to an active sulfenamide.
TALICIA combines two antibacterials -- amoxicillin, which inhibits bacterial cell wall biosynthesis, and rifabutin, which inhibits DNA-dependent RNA polymerase in susceptible organisms -- with omeprazole magnesium, a proton pump inhibitor that suppresses gastric acid secretion by irreversibly binding parietal cell H+/K+ ATPase, thereby raising intragastric pH to support antibacterial efficacy against H. pylori.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Aciphex
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (1/12)
Talicia
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Aciphex
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Talicia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Aciphex
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (3/3)
Talicia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Aciphex.
No savings programs available for Talicia.
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AciphexView full Aciphex profile
TaliciaView full Talicia profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.