| Lupus Nephritis
Lupkynis vs Gazyva
Side-by-side clinical, coverage, and cost comparison for lupus nephritis.Deep comparison between: Lupkynis vs Gazyva with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsGazyva has a higher rate of injection site reactions vs Lupkynis based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Gazyva but not Lupkynis, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Lupkynis
Gazyva
At A Glance
Oral
Twice daily
Calcineurin inhibitor
IV infusion
Anti-CD20 monoclonal antibody
Indications
- Lupus Nephritis
- Chronic Lymphocytic Leukemia
- Lymphoma, Follicular
- Lupus Nephritis
Dosing
Lupus Nephritis 23.7 mg orally twice daily on an empty stomach (minimum 8 hours between doses), in combination with mycophenolate mofetil and corticosteroids; dose adjusted based on eGFR and blood pressure monitoring.
Severe renal impairment (baseline eGFR <45 mL/min/1.73 m2) Recommended starting dose is 15.8 mg twice daily if benefit exceeds risk.
Mild or moderate hepatic impairment (Child-Pugh A or B) Recommended dose is 15.8 mg twice daily; not recommended in severe hepatic impairment (Child-Pugh C).
Dose adjustment with moderate CYP3A4 inhibitors Reduce daily dosage to 15.8 mg in the morning and 7.9 mg in the evening when co-administered with moderate CYP3A4 inhibitors (e.g., verapamil, fluconazole, diltiazem).
Chronic Lymphocytic Leukemia 100 mg IV on day 1 and 900 mg on day 2 of Cycle 1, then 1,000 mg on days 8 and 15 of Cycle 1, and 1,000 mg on day 1 of Cycles 2-6 (28-day cycles) in combination with chlorambucil.
Lymphoma, Follicular 1,000 mg IV on days 1, 8, and 15 of Cycle 1, then 1,000 mg on day 1 of Cycles 2-6 or 2-8 in combination with chemotherapy; responding patients continue on 1,000 mg monotherapy every 2 months for up to 2 years.
Lupus Nephritis 1,000 mg IV at initial infusion (Dose 1), at Week 2 (Dose 2), at Week 24 (Dose 3), at Week 26 (Dose 4), then 1,000 mg every 6 months thereafter, in combination with standard therapy.
Contraindications
- Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin), which significantly increase voclosporin exposure and may increase the risk of nephrotoxicity
- History of serious or severe hypersensitivity reaction, including anaphylaxis, to voclosporin or any of its excipients
- Known hypersensitivity reaction (e.g., anaphylaxis) to obinutuzumab or any excipient
- Serum sickness with prior obinutuzumab use
Adverse Reactions
Most common (>=3%) GFR decreased, hypertension, diarrhea, headache, anemia, cough, urinary tract infection, abdominal pain upper, dyspepsia, alopecia, renal impairment, abdominal pain, mouth ulceration, fatigue, tremor, acute kidney injury, decreased appetite
Serious Lymphoma and other malignancies, serious infections (pneumonia, gastroenteritis, urinary tract infections), nephrotoxicity, hypertension, neurotoxicity (seizure, posterior reversible encephalopathy syndrome), hyperkalemia, QTc prolongation, hypersensitivity reactions, pure red cell aplasia
Postmarketing Hypersensitivity reactions including anaphylaxis and angioedema, nausea, vomiting
Most common (>=10%) Infusion-related reactions, neutropenia, thrombocytopenia, diarrhea, fatigue, upper respiratory tract infection, musculoskeletal pain
Serious Hepatitis B virus reactivation, progressive multifocal leukoencephalopathy, infusion-related reactions, hypersensitivity reactions including serum sickness, tumor lysis syndrome, infections, neutropenia, thrombocytopenia, disseminated intravascular coagulation
Postmarketing Serum sickness
Pharmacology
Voclosporin is a calcineurin-inhibitor immunosuppressant that inhibits lymphocyte proliferation, T-cell cytokine production, and T-cell activation surface antigen expression by blocking NFATc dephosphorylation; it also stabilizes actin cytoskeleton and stress fibers in podocytes, increasing podocyte integrity in glomeruli.
Obinutuzumab is a humanized anti-CD20 IgG1 monoclonal antibody with reduced fucose content that mediates B-cell lysis via immune effector cell engagement (ADCC and ADCP), direct intracellular death signaling, and complement activation; its reduced fucose content confers greater ADCC activity than rituximab.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Lupkynis
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (10/12)
Gazyva
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Lupkynis
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (5/8)
Gazyva
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lupkynis
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Gazyva
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10
Aurinia Alliance: LupkynisCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Chronic Lymphocytic Leukemia (CLL)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
LupkynisView full Lupkynis profile
GazyvaView full Gazyva profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.