| Lymphoma, T-Cell, Cutaneous
Targretin Capsules vs Targretin Gel
Side-by-side clinical, coverage, and cost comparison for lymphoma, t-cell, cutaneous.Deep comparison between: Targretin vs Targretin with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTargretin has a higher rate of injection site reactions vs Targretin based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Targretin but not Targretin, including UnitedHealthcare
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Category
Targretin
Targretin
At A Glance
Oral
Daily
RXR agonist
Topical
Two to four times daily
RXR agonist
Indications
- Lymphoma, T-Cell, Cutaneous
- Lymphoma, T-Cell, Cutaneous
Dosing
Lymphoma, T-Cell, Cutaneous Initial dose 300 mg/m2/day as a single oral daily dose with a meal; may be reduced to 200 or 100 mg/m2/day or temporarily suspended for toxicity; may be escalated to 400 mg/m2/day after 8 weeks if no tumor response and 300 mg/m2/day is well tolerated.
Lymphoma, T-Cell, Cutaneous Start with once every other day; increase weekly to once, twice, three, then four times daily as tolerated; apply a generous coating to cover lesions, avoiding normal surrounding skin and mucosal surfaces; do not use occlusive dressings.
Contraindications
- Pregnancy
- Known serious hypersensitivity to bexarotene or other components of the product
- Known hypersensitivity to bexarotene or other components of the product
- Pregnancy: must not be given to a pregnant woman or a woman who intends to become pregnant
Adverse Reactions
Most common (>=10%) Hyperlipemia, hypercholesteremia, hypothyroidism, headache, asthenia, infection, rash, dry skin, exfoliative dermatitis, leukopenia, nausea, peripheral edema
Serious Hyperlipidemia, pancreatitis, hepatotoxicity, cholestasis, hepatic failure, hypothyroidism, neutropenia, cataracts, hypoglycemia in patients with diabetes mellitus, photosensitivity
Most common (>=10%) Rash, pruritus, skin disorder, pain, infection, headache, contact dermatitis, edema, hyperlipemia
Pharmacology
Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRalpha, RXRbeta, RXRgamma), which function as transcription factors regulating genes that control cellular differentiation and proliferation; the exact mechanism of action in CTCL is unknown.
Bexarotene selectively binds and activates retinoid X receptor (RXR) subtypes (RXRalpha, RXRbeta, RXRgamma), which form heterodimers with various receptor partners and function as transcription factors regulating genes that control cellular differentiation and proliferation; the exact mechanism in CTCL is unknown.
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Most Common Insurance
Anthem BCBS
Targretin
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
Targretin
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Targretin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Targretin
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (5/8)
Humana
Targretin
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Targretin
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableBausch Health Patient Assistance Program
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableBausch Health Patient Assistance Program
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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TargretinView full Targretin profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.