| Macular edema due to diabetes mellitus
Susvimo vs Vabysmo
Side-by-side clinical, coverage, and cost comparison for macular edema due to diabetes mellitus.Deep comparison between: Susvimo vs Vabysmo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVabysmo has a higher rate of injection site reactions vs Susvimo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vabysmo but not Susvimo, including UnitedHealthcare
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Category
Susvimo
Vabysmo
At A Glance
Ocular implant (intravitreal)
Every 24-36 weeks
VEGF-A antagonist
Intravitreal injection
Every 4-8 weeks
VEGF-A and Ang-2 inhibitor
Indications
- Wet age-related macular degeneration
- Macular edema due to diabetes mellitus
- Diabetic Retinopathy
- Exudative age-related macular degeneration
- Macular edema due to diabetes mellitus
- Macular retinal edema
Dosing
Wet age-related macular degeneration, Macular edema due to diabetes mellitus 2 mg (0.02 mL of 100 mg/mL solution) continuously delivered via the SUSVIMO ocular implant with refills every 24 weeks (approximately 6 months).
Diabetic Retinopathy 2 mg (0.02 mL of 100 mg/mL solution) continuously delivered via the SUSVIMO ocular implant with refills every 36 weeks (approximately 9 months).
Exudative age-related macular degeneration 6 mg (0.05 mL) by intravitreal injection every 4 weeks for first 4 doses, followed by dosing every 8, 12, or 16 weeks based on OCT and visual acuity evaluations; some patients may need every 4-week dosing.
Macular edema due to diabetes mellitus 6 mg (0.05 mL) by intravitreal injection every 4 weeks for at least 4-6 doses, then interval adjusted to every 4-8 weeks based on CST and visual acuity evaluations.
Macular retinal edema 6 mg (0.05 mL) by intravitreal injection every 4 weeks.
Contraindications
- Ocular or periocular infections
- Active intraocular inflammation
- Known hypersensitivity to ranibizumab products or any excipient in SUSVIMO
- Ocular or periocular infection
- Active intraocular inflammation
- Known hypersensitivity to faricimab or any excipient in VABYSMO
Adverse Reactions
Most common (>=10%) Conjunctival hemorrhage, conjunctival hyperemia, iritis, eye pain, cataract, conjunctival disorder, vitreous hemorrhage
Serious Endophthalmitis, rhegmatogenous retinal detachment, implant dislocation, septum dislodgement, vitreous hemorrhage, conjunctival erosion or retraction, conjunctival bleb, postoperative decrease in visual acuity
Most common (>=1%) Conjunctival hemorrhage, cataract, vitreous detachment, vitreous floaters, intraocular pressure increased, eye pain, intraocular inflammation, retinal pigment epithelial tear, eye irritation, lacrimation increased, ocular discomfort
Serious Endophthalmitis, retinal detachment, increase in intraocular pressure, thromboembolic events, retinal vasculitis and/or retinal vascular occlusion
Postmarketing Retinal vasculitis with or without retinal vascular occlusion
Pharmacology
Ranibizumab is a recombinant humanized IgG1 kappa monoclonal antibody fragment that binds to multiple biologically active forms of VEGF-A, blocking interaction with VEGFR1 and VEGFR2 on endothelial cells and thereby inhibiting neovascularization and vascular leakage.
Faricimab is a humanized bispecific antibody that inhibits two pathways by binding to VEGF-A and Ang-2; VEGF-A inhibition suppresses endothelial cell proliferation, neovascularization, and vascular permeability, while Ang-2 inhibition promotes vascular stability and desensitizes blood vessels to the effects of VEGF-A.
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Most Common Insurance
Anthem BCBS
Susvimo
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (0/12)
Vabysmo
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Susvimo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Vabysmo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Susvimo
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Vabysmo
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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SusvimoView full Susvimo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.