| Menorrhagia

Liletta vs Mirena

Side-by-side clinical, coverage, and cost comparison for menorrhagia.

Deep comparison between: Liletta vs Mirena with Prescriber.AI

AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.

Safety signalsMirena has a higher rate of injection site reactions vs Liletta based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Mirena but not Liletta, including UnitedHealthcare

Category

Liletta

Mirena

At A Glance

RouteIntrauterine

FrequencySingle insertion

ClassProgestin-releasing IUS

RouteIntrauterine (IUS)

FrequencyContinuous release

ClassProgestin IUS

Indications

Menorrhagia

Menorrhagia

Dosing

Contraception Single intrauterine insertion; remove by end of eighth year; may be replaced at time of removal for continued contraception.

Menorrhagia Single intrauterine insertion; replace by end of fifth year if continued treatment of heavy menstrual bleeding is needed.

Contraception Insert 52 mg LNG intrauterine system by a trained healthcare provider using aseptic technique; releases approximately 21 mcg/day initially, declining to approximately 7 mcg/day by year 8; replace by the end of the eighth year.

Menorrhagia Insert 52 mg LNG intrauterine system by a trained healthcare provider using aseptic technique; replace by the end of the fifth year if continued treatment is needed.

Contraindications

Pregnancy
Use as post-coital contraception (emergency contraception)
Congenital or acquired uterine anomaly, including leiomyomas, that distorts the uterine cavity
Acute pelvic inflammatory disease (PID)
Postpartum endometritis or infected abortion in the past 3 months
Known or suspected uterine or cervical malignancy
Known or suspected breast cancer or other hormone-sensitive cancer, now or in the past
Uterine bleeding of unknown etiology
Untreated acute cervicitis or vaginitis, including bacterial vaginosis, chlamydial or gonococcal cervical infection, or other lower genital tract infections until infection is controlled
Acute liver disease or liver tumor (benign or malignant)
Conditions associated with increased susceptibility to pelvic infections
A previously inserted IUS that has not been removed
History of hypersensitivity reaction to any component of LILETTA

Pregnancy or suspected pregnancy
Intended use as post-coital (emergency) contraception
Congenital or acquired uterine anomaly, including fibroids, distorting the uterine cavity
Acute pelvic inflammatory disease (PID) or history of PID without a subsequent intrauterine pregnancy
Postpartum endometritis or infected abortion within the past 3 months
Known or suspected uterine or cervical malignancy
Known or suspected breast cancer or other progestin-sensitive cancer, current or past
Uterine bleeding of unknown etiology
Untreated acute cervicitis or vaginitis, including bacterial vaginosis, until infection is controlled
Acute liver disease or liver tumor (benign or malignant)
Conditions associated with increased susceptibility to pelvic infections
Previously inserted IUD that has not been removed
Hypersensitivity to any component of Mirena

Drug Interactions

475View drug interactions

Adverse Reactions

Most common (>=5%) Vulvovaginal mycotic infections, vaginal bacterial infections, acne, nausea or vomiting, headache, breast tenderness or pain, abdominal discomfort or pain, dyspareunia, anxiety, depression, pelvic discomfort or pain, dysmenorrhea, mood changes, back pain, weight increased, vaginal discharge

Serious Ectopic pregnancy, ovarian cysts, IUS perforation requiring laparoscopic surgery

Postmarketing Arterial thrombotic and venous thromboembolic events (pulmonary emboli, deep vein thrombosis, stroke), hypersensitivity reactions (rash, urticaria, angioedema), increased blood pressure, dizziness, device breakage

Most common (>=10%) Alterations of menstrual bleeding patterns (unscheduled uterine bleeding, decreased uterine bleeding, increased scheduled uterine bleeding), abdominal/pelvic pain, amenorrhea, headache/migraine, genital discharge, vulvovaginitis

Serious Ectopic pregnancy, intrauterine pregnancy, Group A Streptococcal sepsis, pelvic inflammatory disease, uterine perforation, expulsion, ovarian cysts

Postmarketing Arterial thrombotic and venous thromboembolic events (pulmonary embolism, deep vein thrombosis, stroke), device breakage, hypersensitivity (rash, urticaria, angioedema), increased blood pressure

Pharmacology

Levonorgestrel-releasing intrauterine system; locally released LNG prevents pregnancy by thickening cervical mucus to inhibit sperm passage, inhibiting sperm mobility and capacitation, and altering the endometrium.

Levonorgestrel-releasing intrauterine system; works locally by thickening cervical mucus to prevent sperm passage, inhibiting sperm capacitation or survival, and altering the endometrium; ovulation is inhibited in some but not all users.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Liletta