| Metastatic castration-resistant prostate cancer
Yonsa vs Zytiga
Side-by-side clinical, coverage, and cost comparison for metastatic castration-resistant prostate cancer.Deep comparison between: Yonsa vs Zytiga with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZytiga has a higher rate of injection site reactions vs Yonsa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zytiga but not Yonsa, including UnitedHealthcare
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Category
Yonsa
Zytiga
At A Glance
Oral
Daily
CYP17 inhibitor
Oral
Daily
CYP17 inhibitor
Indications
- Metastatic castration-resistant prostate cancer
- Metastatic castration-resistant prostate cancer
- Metastatic Castration-Sensitive Prostate Carcinoma
Dosing
Metastatic castration-resistant prostate cancer 500 mg (four 125 mg tablets) orally once daily with or without food in combination with methylprednisolone 4 mg twice daily; concurrent GnRH analog or bilateral orchiectomy required.
Metastatic castration-resistant prostate cancer 1,000 mg orally once daily with prednisone 5 mg orally twice daily; take on an empty stomach (no food 2 hours before or 1 hour after).
Metastatic Castration-Sensitive Prostate Carcinoma 1,000 mg orally once daily with prednisone 5 mg orally once daily; take on an empty stomach (no food 2 hours before or 1 hour after).
Contraindications
—
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Adverse Reactions
Most common (>10%) Fatigue, joint swelling or discomfort, edema, hot flush, diarrhea, vomiting, cough, hypertension, dyspnea, urinary tract infection, contusion.
Serious Cardiac failure, arrhythmia, hepatotoxicity, hypokalemia, fluid retention.
Postmarketing Non-infectious pneumonitis, myopathy including rhabdomyolysis, fulminant hepatitis including acute hepatic failure, QT prolongation and Torsades de Pointes, anaphylactic reactions.
Most common (>=10%) Fatigue, arthralgia, hypertension, nausea, edema, hypokalemia, hot flush, diarrhea, vomiting, upper respiratory infection, cough, headache
Serious Cardiac failure, hepatotoxicity, hypokalemia (Grade 3-4), arrhythmia, cardiorespiratory arrest
Postmarketing Non-infectious pneumonitis, myopathy including rhabdomyolysis, fulminant hepatitis including acute hepatic failure and death, QT prolongation and Torsades de Pointes, anaphylactic reactions
Pharmacology
Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor that selectively inhibits CYP17 (17alpha-hydroxylase/C17,20-lyase), blocking androgen production in testicular, adrenal, and prostatic tumor tissues to suppress androgen-sensitive prostate cancer growth.
Abiraterone acetate is converted in vivo to abiraterone, a selective inhibitor of CYP17 (17alpha-hydroxylase/C17,20-lyase) that blocks androgen biosynthesis in testicular, adrenal, and prostatic tumor tissues, thereby reducing serum testosterone and other androgens in patients with prostate cancer.
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Most Common Insurance
Anthem BCBS
Yonsa
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (10/12)
Zytiga
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (4/12) · Qty limit (9/12)
UnitedHealthcare
Yonsa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Zytiga
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Yonsa
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Zytiga
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Prostate Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$10/momo
Janssen CarePath Savings Program: ZytigaCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.