| Metastatic non-small cell lung cancer
Tabrecta vs Vizimpro
Side-by-side clinical, coverage, and cost comparison for metastatic non-small cell lung cancer.Deep comparison between: Tabrecta vs Vizimpro with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVizimpro has a higher rate of injection site reactions vs Tabrecta based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vizimpro but not Tabrecta, including UnitedHealthcare
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Category
Tabrecta
Vizimpro
At A Glance
Oral
Twice daily
MET kinase inhibitor
Oral
Daily
EGFR inhibitor
Indications
- Metastatic non-small cell lung cancer
- Metastatic non-small cell lung cancer
Dosing
Metastatic non-small cell lung cancer 400 mg orally twice daily with or without food; swallow tablets whole.
Metastatic non-small cell lung cancer 45 mg orally once daily until disease progression or unacceptable toxicity; may be taken with or without food.
Contraindications
—
—
Adverse Reactions
Most common (>=20%) Edema, nausea, musculoskeletal pain, fatigue, vomiting, dyspnea, cough, decreased appetite
Serious Dyspnea, pneumonia, pleural effusion, musculoskeletal pain, general physical health deterioration, ILD/pneumonitis, edema, vomiting
Most common (>20%) Diarrhea, rash, paronychia, stomatitis, decreased appetite, dry skin, decreased weight, alopecia, cough, pruritus
Serious Diarrhea, interstitial lung disease
Pharmacology
Capmatinib is a kinase inhibitor that targets MET, including the mutant variant produced by exon 14 skipping, inhibiting MET phosphorylation triggered by hepatocyte growth factor binding or MET amplification, and suppressing downstream signaling, proliferation, and survival of MET-dependent cancer cells.
Dacomitinib is an irreversible inhibitor of the kinase activity of the human EGFR family (EGFR/HER1, HER2, and HER4) and certain EGFR activating mutations (exon 19 deletion or exon 21 L858R substitution mutation), demonstrating dose-dependent inhibition of EGFR and HER2 autophosphorylation and tumor growth in preclinical models.
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Most Common Insurance
Anthem BCBS
Tabrecta
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
Vizimpro
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Tabrecta
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Vizimpro
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Tabrecta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Vizimpro
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$25/momo
Novartis Oncology Universal Co-pay Program: TabrectaCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Non-Small Cell Lung Cancer (NSCLC)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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TabrectaView full Tabrecta profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.