| Multiple Sclerosis, Relapsing-Remitting
Rebif vs Vumerity
Side-by-side clinical, coverage, and cost comparison for multiple sclerosis, relapsing-remitting.Deep comparison between: Rebif vs Vumerity with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVumerity has a higher rate of injection site reactions vs Rebif based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vumerity but not Rebif, including UnitedHealthcare
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Category
Rebif
Vumerity
At A Glance
SC injection
Three times per week
Interferon beta-1a
Oral
Twice daily
Nrf2 pathway activator
Indications
- Clinically isolated syndrome
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis, Secondary Progressive
- Clinically isolated syndrome
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis, Secondary Progressive
Dosing
Clinically isolated syndrome, Multiple Sclerosis Relapsing-Remitting, Multiple Sclerosis Secondary Progressive 22 mcg or 44 mcg SC three times per week; titrate starting at 20% of prescribed dose over a 4-week period to the targeted dose; administer at the same time on the same three days at least 48 hours apart each week.
Clinically isolated syndrome, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive Starting dose 231 mg twice daily orally for 7 days; maintenance dose 462 mg (two 231 mg capsules) twice daily orally; temporary reduction to 231 mg twice daily may be considered for tolerability, resuming 462 mg twice daily within 4 weeks.
Contraindications
- History of hypersensitivity to natural or recombinant interferon beta, human albumin, or any other component of the formulation
- Known hypersensitivity to diroximel fumarate, dimethyl fumarate, or any excipient of VUMERITY (reactions may include anaphylaxis and angioedema)
- Concomitant use of dimethyl fumarate
Adverse Reactions
Most common Injection site reaction, influenza-like symptoms, headache, fatigue, fever, leukopenia, elevated liver enzymes (SGPT, SGOT), myalgia, back pain, abdominal pain, depression
Serious Depression and suicide, hepatic injury, anaphylaxis and other allergic reactions, injection site necrosis, decreased peripheral blood counts, thrombotic microangiopathy, pulmonary arterial hypertension, seizures
Postmarketing Drug-induced lupus erythematosus, autoimmune hepatitis, retinal vascular disorders, pulmonary arterial hypertension, erythema multiforme, Stevens-Johnson syndrome, hemolytic anemia
Most common (>=10%) Flushing, abdominal pain, diarrhea, nausea
Serious Anaphylaxis, angioedema, progressive multifocal leukoencephalopathy, herpes zoster and other serious opportunistic infections, lymphopenia, liver injury, serious gastrointestinal reactions
Postmarketing Acute pancreatitis, gastrointestinal perforation/ulceration/obstruction/hemorrhage, liver function abnormalities (transaminases >=3 times ULN with total bilirubin >2 times ULN), herpes zoster infection, rhinorrhea, alopecia
Pharmacology
Interferon beta-1a; the exact mechanism(s) by which REBIF exerts its therapeutic effects in multiple sclerosis is unknown, but it is a recombinant form of human interferon beta produced in Chinese Hamster Ovary cells with an amino acid sequence identical to natural fibroblast-derived human interferon beta.
Diroximel fumarate is a prodrug converted to its active metabolite monomethyl fumarate (MMF), which activates the Nrf2 pathway involved in cellular response to oxidative stress and acts as a nicotinic acid receptor agonist in vitro; the mechanism by which it exerts therapeutic effect in multiple sclerosis is unknown.
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Most Common Insurance
Anthem BCBS
Rebif
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (9/12)
Vumerity
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (10/12)
UnitedHealthcare
Rebif
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Vumerity
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Rebif
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Vumerity
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Multiple Sclerosis - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Multiple Sclerosis - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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VumerityView full Vumerity profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.