| Multiple Sclerosis, Secondary Progressive
Betaseron vs Briumvi
Side-by-side clinical, coverage, and cost comparison for multiple sclerosis, secondary progressive.Deep comparison between: Betaseron vs Briumvi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsBriumvi has a higher rate of injection site reactions vs Betaseron based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Briumvi but not Betaseron, including UnitedHealthcare
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Category
Betaseron
Briumvi
At A Glance
SC injection
Every other day
Type I interferon
IV infusion
Every 24 weeks
Anti-CD20 monoclonal antibody
Indications
- Multiple Sclerosis, Relapsing-Remitting
- Clinically isolated syndrome
- Multiple Sclerosis, Secondary Progressive
- Multiple Sclerosis, Relapsing-Remitting
- Clinically isolated syndrome
- Multiple Sclerosis, Secondary Progressive
Dosing
Multiple Sclerosis, Relapsing-Remitting, Clinically isolated syndrome, Multiple Sclerosis, Secondary Progressive Start at 0.0625 mg (0.25 mL) SC every other day, titrating over six weeks to the recommended dose of 0.25 mg (1 mL) SC every other day.
Multiple Sclerosis, Relapsing-Remitting; Clinically isolated syndrome; Multiple Sclerosis, Secondary Progressive 150 mg IV infusion (first infusion), followed by 450 mg IV infusion 2 weeks later, then 450 mg IV every 24 weeks; pre-medicate with methylprednisolone (or equivalent corticosteroid) and antihistamine before each infusion.
Contraindications
- History of hypersensitivity to natural or recombinant interferon beta, Albumin (Human), or any other component of the formulation
- Active HBV infection
- History of life-threatening infusion reaction to ublituximab-xiiy
Adverse Reactions
Most common (>=5% difference from placebo) Injection site reaction, lymphopenia, flu-like symptoms, myalgia, leukopenia, neutropenia, increased liver enzymes, headache, hypertonia, pain, rash, insomnia, abdominal pain, asthenia
Serious Hepatic injury, anaphylaxis and allergic reactions, depression and suicide, congestive heart failure, injection site necrosis, leukopenia, thrombotic microangiopathy, pulmonary arterial hypertension, seizures, drug-induced lupus erythematosus
Postmarketing Anemia, thrombocytopenia, hemolytic anemia, hypothyroidism, hyperthyroidism, pancreatitis, bronchospasm, pulmonary arterial hypertension, fatal capillary leak syndrome
Most common (>=10%) Infusion reactions, upper respiratory tract infections
Serious Infusion reactions, infections, reduction in immunoglobulins, liver injury
Postmarketing Liver injury, progressive multifocal leukoencephalopathy
Pharmacology
Interferon beta-1b is a type I interferon that binds to specific receptors on human cell membranes, inducing immunomodulatory effects including enhancement of suppressor T cell activity, reduction of pro-inflammatory cytokine production, down-regulation of antigen presentation, and inhibition of lymphocyte trafficking into the central nervous system; its specific mechanism of action in multiple sclerosis is unknown.
Anti-CD20 chimeric monoclonal IgG1 antibody with reduced fucose content; binds CD20 on pre-B and mature B lymphocytes and causes cell lysis via antibody-dependent cellular cytolysis and complement-dependent cytolysis.
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Most Common Insurance
Anthem BCBS
Betaseron
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Briumvi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Betaseron
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (4/8)
Briumvi
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Betaseron
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (1/3)
Briumvi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Multiple Sclerosis - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Multiple Sclerosis - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.