| Muscular Dystrophy, Duchenne
Exondys 51 vs Amondys 45
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Exondys 51 vs Amondys 45 with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAmondys 45 has a higher rate of injection site reactions vs Exondys 51 based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Amondys 45 but not Exondys 51, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Exondys 51
Amondys 45
At A Glance
IV infusion
Once weekly
Antisense oligonucleotide (exon 51 skipper)
IV infusion
Once weekly
Antisense oligonucleotide (exon 45 skipper)
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 30 mg/kg once weekly as a 35 to 60 minute IV infusion via an in-line 0.2 micron filter.
Muscular Dystrophy, Duchenne 30 mg/kg once weekly as a 35 to 60-minute IV infusion via an in-line 0.2 micron filter.
Contraindications
—
- Known serious hypersensitivity to casimersen or to any of the inactive ingredients in AMONDYS 45
Adverse Reactions
Most common (>=35%) balance disorder, vomiting
Postmarketing bronchospasm, cyanosis of the lips, malaise, pyrexia, flushing, protein urine present, dehydration
Most common (>=20%) Upper respiratory tract infections, cough, pyrexia, headache, arthralgia, oropharyngeal pain
Serious Hypersensitivity reactions including angioedema and anaphylaxis
Postmarketing Infusion-related reactions including rash, headache, cough, abdominal pain, and vomiting; hypersensitivity reactions including angioedema and anaphylaxis
Pharmacology
Eteplirsen is an antisense phosphorodiamidate morpholino oligomer that binds to exon 51 of dystrophin pre-mRNA, causing exon skipping during mRNA processing to allow production of an internally truncated dystrophin protein in patients with DMD mutations amenable to exon 51 skipping.
Casimersen is an antisense oligonucleotide (phosphorodiamidate morpholino oligomer subclass) that binds to exon 45 of dystrophin pre-mRNA, causing exon 45 skipping and production of an internally truncated dystrophin protein in patients with DMD mutations amenable to exon 45 skipping.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Exondys 51
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Amondys 45
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Exondys 51
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Amondys 45
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Exondys 51
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Amondys 45
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
Exondys 51View full Exondys 51 profile
Amondys 45View full Amondys 45 profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.