| Muscular Dystrophy, Duchenne
Vyondys 53 vs Amondys 45
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Vyondys 53 vs Amondys 45 with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAmondys 45 has a higher rate of injection site reactions vs Vyondys 53 based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Amondys 45 but not Vyondys 53, including UnitedHealthcare
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Category
Vyondys 53
Amondys 45
At A Glance
IV infusion
Once weekly
Exon 53 skipping antisense oligonucleotide
IV infusion
Once weekly
Antisense oligonucleotide (exon 45 skipper)
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 30 mg/kg IV infusion once weekly over 35 to 60 minutes via an in-line 0.2 micron filter.
Muscular Dystrophy, Duchenne 30 mg/kg once weekly as a 35 to 60-minute IV infusion via an in-line 0.2 micron filter.
Contraindications
- Serious hypersensitivity reaction to golodirsen or any inactive ingredient in VYONDYS 53
- Known serious hypersensitivity to casimersen or to any of the inactive ingredients in AMONDYS 45
Adverse Reactions
Most common (>=20%) Headache, pyrexia, fall, abdominal pain, nasopharyngitis, cough, vomiting, nausea
Serious Hypersensitivity reactions
Postmarketing Anaphylaxis
Most common (>=20%) Upper respiratory tract infections, cough, pyrexia, headache, arthralgia, oropharyngeal pain
Serious Hypersensitivity reactions including angioedema and anaphylaxis
Postmarketing Infusion-related reactions including rash, headache, cough, abdominal pain, and vomiting; hypersensitivity reactions including angioedema and anaphylaxis
Pharmacology
Golodirsen is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer (PMO) subclass that binds to exon 53 of dystrophin pre-mRNA, inducing exon 53 exclusion during mRNA processing to allow production of an internally truncated dystrophin protein in patients with DMD gene mutations amenable to exon 53 skipping.
Casimersen is an antisense oligonucleotide (phosphorodiamidate morpholino oligomer subclass) that binds to exon 45 of dystrophin pre-mRNA, causing exon 45 skipping and production of an internally truncated dystrophin protein in patients with DMD mutations amenable to exon 45 skipping.
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Most Common Insurance
Anthem BCBS
Vyondys 53
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Amondys 45
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Vyondys 53
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Amondys 45
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Vyondys 53
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Amondys 45
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Vyondys 53View full Vyondys 53 profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.