| MYELODYSPLASTIC SYNDROME
Tibsovo vs Rytelo
Side-by-side clinical, coverage, and cost comparison for myelodysplastic syndrome.Deep comparison between: Tibsovo vs Rytelo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRytelo has a higher rate of injection site reactions vs Tibsovo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rytelo but not Tibsovo, including UnitedHealthcare
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Category
Tibsovo
Rytelo
At A Glance
Oral
Daily
IDH1 inhibitor
IV infusion
Every 4 weeks
Telomerase inhibitor
Indications
- Leukemia, Myelocytic, Acute
- MYELODYSPLASTIC SYNDROME
- Cholangiocarcinoma
- MYELODYSPLASTIC SYNDROME
Dosing
Leukemia, Myelocytic, Acute 500 mg orally once daily; newly diagnosed: in combination with azacitidine 75 mg/m2 SC or IV on Days 1-7 of each 28-day cycle, or as monotherapy, for minimum 6 months; relapsed/refractory: monotherapy until disease progression or unacceptable toxicity.
MYELODYSPLASTIC SYNDROME 500 mg orally once daily as monotherapy until disease progression or unacceptable toxicity; continue for minimum 6 months.
Cholangiocarcinoma 500 mg orally once daily until disease progression or unacceptable toxicity.
MYELODYSPLASTIC SYNDROME 7.1 mg/kg administered as an intravenous infusion over 2 hours every 4 weeks; discontinue if no decrease in RBC transfusion burden after 24 weeks (6 doses) or if unacceptable toxicity occurs.
Contraindications
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Adverse Reactions
Most common (>=25%) leukocytes decreased, diarrhea, hemoglobin decreased, platelets decreased, glucose increased, fatigue, alkaline phosphatase increased, edema, potassium decreased, nausea, vomiting, phosphatase decreased, decreased appetite, sodium decreased, leukocytosis, magnesium decreased, aspartate aminotransferase increased, arthralgia, dyspnea, uric acid increased, abdominal pain, creatinine increased, mucositis, rash, electrocardiogram QT prolonged, differentiation syndrome, calcium decreased, neutrophils decreased, myalgia
Serious differentiation syndrome, electrocardiogram QT prolonged, leukocytosis, Guillain-Barre syndrome
Most common (>=10%) Decreased platelets, decreased white blood cells, decreased neutrophils, increased AST, increased alkaline phosphatase, increased ALT, fatigue, prolonged partial thromboplastin time, arthralgia/myalgia, COVID-19 infections, headache
Serious Sepsis, fracture, cardiac failure, hemorrhage
Pharmacology
Ivosidenib is a small molecule inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme that reduces 2-hydroxyglutarate (2-HG) levels and induces myeloid differentiation in IDH1-mutated AML; in IDH1-mutated cholangiocarcinoma, it also reduces 2-HG levels in tumor tissue.
Imetelstat is an oligonucleotide human telomerase inhibitor that binds to the RNA template region of human telomerase (hTR), inhibiting telomerase enzymatic activity and reducing malignant stem and progenitor cell proliferation while inducing apoptotic cell death in MDS.
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Most Common Insurance
Anthem BCBS
Tibsovo
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (4/12) · Qty limit (12/12)
Rytelo
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Tibsovo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (2/8)
Rytelo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Tibsovo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Rytelo
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Tibsovo.
Cost estimate not availableAccessia Health: Myelodysplastic Syndromes - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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TibsovoView full Tibsovo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.