| Peripheral T-Cell Lymphoma
Adcetris vs Folotyn
Side-by-side clinical, coverage, and cost comparison for peripheral t-cell lymphoma.Deep comparison between: Adcetris vs Folotyn with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFolotyn has a higher rate of injection site reactions vs Adcetris based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Folotyn but not Adcetris, including UnitedHealthcare
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Category
Adcetris
Folotyn
At A Glance
IV infusion
Every 2-3 weeks
CD30-directed antibody-drug conjugate
IV infusion
Once weekly
Dihydrofolate reductase inhibitor
Indications
- Hodgkin Disease
- Angioimmunoblastic Lymphadenopathy
- Peripheral T-Cell Lymphoma
- Mycosis Fungoides
- Diffuse Large B-Cell Lymphoma
- Peripheral T-Cell Lymphoma
Dosing
Hodgkin Disease (previously untreated Stage III/IV, adults) 1.2 mg/kg (max 120 mg) IV in combination with chemotherapy every 2 weeks for a maximum of 12 doses.
Hodgkin Disease (previously untreated high risk, pediatric) 1.8 mg/kg (max 180 mg) IV in combination with chemotherapy every 3 weeks for a maximum of 5 doses.
Hodgkin Disease (post-auto-HSCT consolidation) 1.8 mg/kg (max 180 mg) IV every 3 weeks for a maximum of 16 cycles.
Hodgkin Disease (relapsed) 1.8 mg/kg (max 180 mg) IV every 3 weeks until disease progression or unacceptable toxicity.
Peripheral T-Cell Lymphoma, Angioimmunoblastic Lymphadenopathy (previously untreated) 1.8 mg/kg (max 180 mg) IV in combination with cyclophosphamide, doxorubicin, and prednisone every 3 weeks for 6 to 8 doses.
Peripheral T-Cell Lymphoma (relapsed systemic ALCL) 1.8 mg/kg (max 180 mg) IV every 3 weeks until disease progression or unacceptable toxicity.
Mycosis Fungoides (relapsed pcALCL or CD30-expressing) 1.8 mg/kg (max 180 mg) IV every 3 weeks for a maximum of 16 cycles.
Diffuse Large B-Cell Lymphoma (relapsed or refractory) 1.2 mg/kg (max 120 mg) IV in combination with lenalidomide and a rituximab product every 3 weeks until disease progression or unacceptable toxicity.
Peripheral T-Cell Lymphoma 30 mg/m2 IV over 3-5 minutes once weekly for 6 weeks in 7-week cycles; reduce to 15 mg/m2 for severe renal impairment (eGFR 15-29 mL/min/1.73 m2); avoid in ESRD (eGFR <15 mL/min/1.73 m2) unless benefit justifies risk; pretreat with folic acid 1-1.25 mg orally daily (starting 10 days before first dose) and vitamin B12 1 mg IM every 8-10 weeks (starting within 10 weeks before first dose).
Contraindications
- Concomitant use with bleomycin due to pulmonary toxicity (e.g., interstitial infiltration and/or inflammation)
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Adverse Reactions
Most common (>=20%) Peripheral neuropathy, fatigue, nausea, diarrhea, musculoskeletal pain, pyrexia, rash, upper respiratory tract infection, constipation, alopecia
Serious Febrile neutropenia, pneumonia, hepatotoxicity, peripheral motor neuropathy, pulmonary toxicity, progressive multifocal leukoencephalopathy, tumor lysis syndrome, serious and opportunistic infections
Postmarketing Febrile neutropenia, acute pancreatitis, gastrointestinal complications, hepatotoxicity, progressive multifocal leukoencephalopathy, serious and opportunistic infections, hyperglycemia, noninfectious pulmonary toxicity including pneumonitis and ARDS, toxic epidermal necrolysis
Most common (>=35%) Mucositis, thrombocytopenia, nausea, fatigue
Serious Pyrexia, mucositis, sepsis, febrile neutropenia, dehydration, dyspnea, thrombocytopenia
Postmarketing Toxic epidermal necrolysis
Pharmacology
Brentuximab vedotin is a CD30-directed antibody-drug conjugate (ADC) consisting of a chimeric IgG1 anti-CD30 antibody linked to MMAE, a microtubule-disrupting agent; upon binding to CD30-expressing tumor cells the ADC is internalized and MMAE is released via proteolytic cleavage, disrupting the microtubule network within the cell and inducing cell cycle arrest and apoptosis.
Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase and polyglutamylation by folylpolyglutamyl synthetase, depleting thymidine and other biological molecules dependent on single carbon transfer.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Adcetris
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Folotyn
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Adcetris
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Folotyn
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Adcetris
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Folotyn
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$0/fillfill
Adcetris Co-Pay Savings ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableCancerCare: Non-Hodgkin Lymphoma
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.