| Philadelphia chromosome positive chronic myelogenous leukemia
Iclusig vs Scemblix
Side-by-side clinical, coverage, and cost comparison for philadelphia chromosome positive chronic myelogenous leukemia.Deep comparison between: Iclusig vs Scemblix with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsScemblix has a higher rate of injection site reactions vs Iclusig based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Scemblix but not Iclusig, including UnitedHealthcare
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Category
Iclusig
Scemblix
At A Glance
Oral
Once daily
BCR::ABL kinase inhibitor
Oral
Once or twice daily
BCR-ABL1 tyrosine kinase inhibitor
Indications
- Leukemia, Myelomonocytic, Chronic
- Philadelphia chromosome positive chronic myelogenous leukemia
- Philadelphia chromosome positive chronic myelogenous leukemia
Dosing
Philadelphia chromosome positive chronic myelogenous leukemia 45 mg orally once daily; reduce to 15 mg once daily upon achievement of <=1% BCR::ABL IS.
AP-CML, BP-CML 45 mg orally once daily.
Newly diagnosed Ph+ ALL 30 mg orally once daily in combination with chemotherapy; reduce to 15 mg once daily upon achievement of MRD-negative CR at the end of induction.
Ph+ ALL (monotherapy, T315I-positive or no other KI indicated) 45 mg orally once daily.
Philadelphia chromosome positive chronic myelogenous leukemia in chronic phase 80 mg orally once daily or 40 mg orally twice daily, taken without food; avoid food for at least 2 hours before and 1 hour after each dose.
Philadelphia chromosome positive chronic myelogenous leukemia in chronic phase with T315I mutation 200 mg orally twice daily at approximately 12-hour intervals, taken without food; avoid food for at least 2 hours before and 1 hour after each dose.
Contraindications
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Adverse Reactions
Most common (>20%) Rash, arthralgia, abdominal pain, fatigue, headache, constipation, hypertension, dry skin, hepatotoxicity, fluid retention and edema, pyrexia, pancreatitis/lipase elevation, nausea, hemorrhage, anemia, arterial occlusive events, cardiac arrhythmias
Serious Arterial occlusive events, venous thromboembolic events, heart failure, hepatotoxicity, hypertension, pancreatitis, neuropathy, ocular toxicity, hemorrhage, fluid retention, cardiac arrhythmias, myelosuppression, tumor lysis syndrome, reversible posterior leukoencephalopathy syndrome, impaired wound healing, gastrointestinal perforation
Postmarketing Thrombotic microangiopathy, hyperthyroidism, gastrointestinal perforation, fistula, dehydration, reversible posterior leukoencephalopathy syndrome, severe cutaneous reactions (erythema multiforme, Stevens-Johnson syndrome), impaired wound healing, panniculitis, arterial aneurysms/dissections/rupture
Most common (>=20%) Musculoskeletal pain, rash, fatigue, upper respiratory tract infection, headache, abdominal pain, arthralgia, diarrhea
Serious Myelosuppression, pancreatic toxicity, hypertension, hypersensitivity, cardiovascular toxicity
Pharmacology
Ponatinib is a kinase inhibitor that inhibits the tyrosine kinase activity of ABL and T315I mutant ABL, as well as VEGFR, PDGFR, FGFR, EPH receptor, and SRC family kinases, KIT, RET, TIE2, and FLT3, suppressing viability of cells expressing native or mutant BCR::ABL including T315I.
Asciminib is an ABL/BCR-ABL1 tyrosine kinase inhibitor that inhibits the ABL1 kinase activity of the BCR::ABL1 fusion protein by binding to the ABL myristoyl pocket, with activity against wild-type BCR::ABL1 and several mutant forms including the T315I mutation.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Iclusig
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
Scemblix
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Iclusig
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Scemblix
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (5/8)
Humana
Iclusig
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Scemblix
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Chronic Myeloid Leukemia (C.M.L.) - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Chronic Myeloid Leukemia (C.M.L.) - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.