| Pulmonary arterial hypertension

Letairis vs Tadliq

Side-by-side clinical, coverage, and cost comparison for pulmonary arterial hypertension.

Deep comparison between: Letairis vs Tadliq with Prescriber.AI

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Safety signalsTadliq has a higher rate of injection site reactions vs Letairis based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Tadliq but not Letairis, including UnitedHealthcare

Category

Letairis

Tadliq

At A Glance

RouteOral

FrequencyDaily

ClassEndothelin receptor antagonist

RouteOral

FrequencyOnce daily

ClassPDE5 inhibitor

Indications

Pulmonary arterial hypertension

Pulmonary arterial hypertension

Dosing

Pulmonary arterial hypertension Initiate at 5 mg once daily, with or without tadalafil 20 mg once daily; titrate at 4-week intervals as needed and tolerated to Letairis 10 mg or tadalafil 40 mg; do not split, crush, or chew tablets.

Pulmonary arterial hypertension 40 mg (10 mL) once daily with or without food; start at 20 mg (5 mL) once daily in mild-to-moderate renal or mild-to-moderate hepatic impairment, increasing to 40 mg based on tolerability; avoid in severe renal impairment and severe hepatic impairment; when initiating TADLIQ in patients on ritonavir for at least one week, start at 20 mg once daily and increase to 40 mg based on tolerability; when starting ritonavir in patients already on TADLIQ, stop TADLIQ at least 24 hours prior and resume at 20 mg once daily after at least one week.

Contraindications

Pregnancy (Letairis may cause fetal harm when administered to a pregnant female)
Idiopathic Pulmonary Fibrosis, including IPF patients with pulmonary hypertension (WHO Group 3)

Concomitant use of any form of organic nitrate, either regularly or intermittently
Concomitant use of guanylate cyclase (GC) stimulators such as riociguat
Known serious hypersensitivity to tadalafil (TADLIQ, ADCIRCA, or CIALIS)

Drug Interactions

1116View drug interactions

1155View drug interactions

Adverse Reactions

Most common (>3% placebo-adjusted) Peripheral edema, nasal congestion, sinusitis, flushing

Postmarketing Anemia requiring transfusion, heart failure (associated with fluid retention), symptomatic hypotension, hypersensitivity (angioedema, rash), liver aminotransferase elevations (ALT, AST)

Most common (>=9%) Headache, myalgia, nasopharyngitis, flushing, respiratory tract infection, pain in extremity, nausea, back pain, dyspepsia, nasal congestion

Serious Hypotension, visual loss, hearing loss, priapism

Postmarketing Serious cardiovascular events (myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations, tachycardia), hypersensitivity reactions (urticaria, Stevens-Johnson syndrome, exfoliative dermatitis), migraine, seizure, transient global amnesia, visual field defect, retinal vein occlusion, retinal artery occlusion, NAION, sudden hearing decrease or loss, priapism

Pharmacology

Ambrisentan is a high-affinity, selective ETA receptor antagonist that blocks the vasoconstriction and cell proliferation mediated by endothelin-1 (ET-1) in pulmonary vasculature, where ET-1 concentrations and mRNA are markedly elevated in PAH patients.

PDE5 inhibitor; tadalafil selectively inhibits phosphodiesterase type 5, increasing cGMP concentrations in pulmonary vascular smooth muscle, resulting in relaxation and vasodilation of the pulmonary vascular bed in patients with pulmonary arterial hypertension.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Letairis