| Pyelonephritis
Zerbaxa vs Vabomere
Side-by-side clinical, coverage, and cost comparison for pyelonephritis.Deep comparison between: Zerbaxa vs Vabomere with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVabomere has a higher rate of injection site reactions vs Zerbaxa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vabomere but not Zerbaxa, including UnitedHealthcare
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Category
Zerbaxa
Vabomere
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
IV infusion
Every 8 hours
Carbapenem + beta-lactamase inhibitor
Indications
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
- Complicated urinary tract infection
- Pyelonephritis
Dosing
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Complicated urinary tract infection, Pyelonephritis 4 grams (meropenem 2 grams and vaborbactam 2 grams) IV infusion over 3 hours every 8 hours for up to 14 days in patients with eGFR >=50 mL/min/1.73m2; dose adjustment required for eGFR <50 mL/min/1.73m2 (2 grams every 8 hours for eGFR 30-49, 2 grams every 12 hours for eGFR 15-29, 1 gram every 12 hours for eGFR <15).
Contraindications
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
- Known hypersensitivity to any component of VABOMERE (meropenem and vaborbactam) or to other drugs in the same class
- Demonstrated anaphylactic reactions to beta-lactam antibacterial drugs
Adverse Reactions
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Most common (>=3%) Headache, phlebitis/infusion site reactions, diarrhea
Serious Hypersensitivity reactions, seizures, rhabdomyolysis, Clostridioides difficile-associated diarrhea, breakthrough seizures (valproic acid interaction), thrombocytopenia, neuromotor impairment
Postmarketing Rhabdomyolysis, drug-induced liver injury (DILI) including hepatitis and liver failure
Pharmacology
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
Meropenem is a penem antibacterial that inhibits bacterial cell wall synthesis by binding penicillin-binding proteins in gram-positive and gram-negative bacteria; vaborbactam is a cyclic boronic acid, non-suicidal beta-lactamase inhibitor that protects meropenem from degradation by serine beta-lactamases, including Klebsiella pneumoniae carbapenemase (KPC), without intrinsic antibacterial activity.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Vabomere
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Vabomere
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Vabomere
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zerbaxa.
No savings programs available for Vabomere.
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ZerbaxaView full Zerbaxa profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.