| Rosacea
Oracea vs Rhofade
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Oracea vs Rhofade with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRhofade has a higher rate of injection site reactions vs Oracea based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rhofade but not Oracea, including UnitedHealthcare
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Category
Oracea
Rhofade
At A Glance
Oral
Daily
Tetracycline-class antibiotic
Topical
Daily
Alpha-1A adrenoceptor agonist
Indications
- Rosacea
- Rosacea
Dosing
Rosacea 40 mg once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals, administered orally.
Rosacea Apply a pea-sized amount once daily in a thin layer to cover the entire face (forehead, nose, each cheek, and chin), avoiding the eyes and lips; wash hands immediately after applying.
Contraindications
- Hypersensitivity to doxycycline or any of the other tetracyclines
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Adverse Reactions
Most common (>=1%) nasopharyngitis, diarrhea, hypertension, sinusitis, fungal infection, influenza, aspartate aminotransferase increase, blood pressure increase, anxiety, pain, abdominal pain upper, blood lactate dehydrogenase increase, nasal congestion, abdominal distention, abdominal pain, stomach discomfort, dry mouth, blood glucose increase, back pain, sinus headache, pharyngolaryngeal pain
Serious hepatotoxicity, esophagitis, esophageal ulcerations, renal toxicity (rise in BUN), exfoliative dermatitis, photosensitivity, urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus, hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Postmarketing pseudotumor cerebri (benign intracranial hypertension), headache, fixed drug eruption, depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Most common (>=1%) application site dermatitis, worsening inflammatory lesions of rosacea, application site pruritus, application site erythema, application site pain
Pharmacology
Doxycycline is a member of the tetracycline-class of drugs; the plasma concentrations achieved with ORACEA are sub-antimicrobial, and the mechanism of action in the treatment of inflammatory lesions of rosacea is unknown.
Oxymetazoline is an alpha 1A adrenoceptor agonist that acts as a vasoconstrictor when applied topically to the face.
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Most Common Insurance
Anthem BCBS
Oracea
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (9/12) · Qty limit (10/12)
Rhofade
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (6/12) · Qty limit (9/12)
UnitedHealthcare
Oracea
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Rhofade
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Oracea
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Rhofade
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Oracea.
No savings programs available for Rhofade.
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OraceaView full Oracea profile
RhofadeView full Rhofade profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.